ArticleJournal of the American Chemical Society2023
Triggered Polymersome Fusion.
Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Light-Controlled Membrane Fusion in Synthetic Cells.Life (Basel, Switzerland) · 2026Review
- Membrane Fusion-Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics.Advanced healthcare materials · 2026Review
- A 3D printed capillary holder design for reliable stopped-flow SAX experiments.Journal of synchrotron radiation · 2026Article
- Kinetically controlled hetero-fusion is a systems-level behaviour of polymer nanoparticle populations.Nature communications · 2025Article
- Self-reproduction as an autonomous process of growth and reorganization in fully abiotic, artificial and synthetic cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Characterization and Optimization of Vesicle Properties in bioPISA: from Size Distribution to Post-Assembly Loading.Advanced biology · 2025Article
- Designing polymersomes with surface-integrated nanoparticles through hierarchical phase separation.Nature communications · 2025Article
- Vaccine delivery systems and administration routes: Advanced biotechnological techniques to improve the immunization efficacy.Vaccine: X · 2024Review
- Kinetically Controlled and Nonequilibrium Assembly of Block Copolymers in Solution.Journal of the American Chemical Society · 2024Review
- Shape Transformation of Polymer Vesicles.Accounts of materials research · 2024Article
- Controlled node growth on the surface of polymersomes.Chemical science · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contents of biological cells are retained within compartments formed of phospholipid membranes. The movement of material within and between cells is often mediated by the fusion of phospholipid membranes, which allows mixing of contents or excretion of material into the surrounding environment. Biological membrane fusion is a highly regulated process that is catalyzed by proteins and often triggered by cellular signaling. In contrast, the controlled fusion of polymer-based membranes is largely unexplored, despite the potential application of this process in nanomedicine, smart materials, and reagent trafficking. Here, we demonstrate triggered polymersome fusion. Out-of-equilibrium polymersomes were formed by ring-opening metathesis polymerization-induced self-assembly and persist until a specific chemical signal (pH change) triggers their fusion. Characterization of polymersomes was performed by a variety of techniques, including dynamic light scattering, dry-state/cryogenic-transmission electron microscopy, and small-angle X-ray scattering (SAXS). The fusion process was followed by time-resolved SAXS analysis. Developing elementary methods of communication between polymersomes, such as fusion, will prove essential for emulating life-like behaviors in synthetic nanotechnology.
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