ArticleeLife2023
Cellular compartmentalisation and receptor promiscuity as a strategy for accurate and robust inference of position during morphogenesis.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Stable developmental patterns of gene expression without morphogen gradients.PLoS computational biology · 2024Article
- Multi-Grid Reaction-Diffusion Master Equation: Applications to Morphogen Gradient Modelling.Bulletin of mathematical biology · 2024Article
- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- High-affinity biomolecular interactions are modulated by low-affinity binders.NPJ systems biology and applications · 2024Article
- Optimizing information transmission in optogenetic Wnt signaling.Physical review researchArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Precise spatial patterning of cell fate during morphogenesis requires accurate inference of cellular position. In making such inferences from morphogen profiles, cells must contend with inherent stochasticity in morphogen production, transport, sensing and signalling. Motivated by the multitude of signalling mechanisms in various developmental contexts, we show how cells may utilise multiple tiers of processing (compartmentalisation) and parallel branches (multiple receptor types), together with feedback control, to bring about fidelity in morphogenetic decoding of their positions within a developing tissue. By simultaneously deploying specific and nonspecific receptors, cells achieve a more accurate and robust inference. We explore these ideas in the patterning of
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.