Evidence map›Paper›PMID 36877416›Full record

ArticleJournal of molecular histology2023

Allograft inflammatory factor-1 released from the cerebral microglia affect several organs in the body.

Mai Fukasawa, Kensuke Nishio, Daichi Oikawa, Tomoka Itou, Toshimitsu Iinuma, Masatake Asano

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular histology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. International journal of molecular sciences · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mai FukasawaDepartment of Complete Denture Prosthodontics, Nihon University School of Dentistry, Tokyo, Japan.
Kensuke NishioDepartment of Complete Denture Prosthodontics, Nihon University School of Dentistry, Tokyo, Japan.
Daichi OikawaDepartment of Complete Denture Prosthodontics, Nihon University School of Dentistry, Tokyo, Japan.
Tomoka ItouDepartment of Complete Denture Prosthodontics, Nihon University School of Dentistry, Tokyo, Japan.
Toshimitsu IinumaDepartment of Complete Denture Prosthodontics, Nihon University School of Dentistry, Tokyo, Japan.
Masatake AsanoDepartment of Pathology, Nihon University School of Dentistry, Tokyo, Japan. asano.masatake@nihon-u.ac.jp.ORCID http://orcid.org/0000-0003-0028-8262
Nihon University · JP

Funding

Grant-in-aid for Scientific Research (C) 2 0 K 1 0 0 5 7
6 · The paper itself

Abstract

Allograft inflammatory factor-1 (AIF-1) is expressed in microglia. Unilateral common carotid artery occlusion (UCCAO) was conducted to elucidate mechanisms that regulate AIF-1 expression in C57BL/6 male mice. Immunohistochemical reactivity of microglia against anti-AIF-1 antibody was increased significantly in the brain of this model. The increased AIF-1 production was further confirmed by ELISA using brain homogenate. Real-time PCR demonstrated that the increased AIF-1 production was regulated at the transcriptional level. Serum AIF-1 levels were further examined by ELISA and marked increase was observed on Day 1 of UCCAO. To examine the influence of AIF-1, immunohistochemical staining was performed and revealed that the immunoreactivity against anti-Iba-1 antibody was significantly increased in various organs. Among them, the accumulation of Iba-1

Indexed as

BrainMicrogliaAllograftsAnimalsMaleMiceMice, Inbred C57BLRNA, MessengerRNA, MessengerAllograft inflammatory factor-1AutocrineCerebral ischemiaHypoxia

Identifiers

PMID36877416
OpenAlexW4323294547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.