Evidence map›Paper›PMID 36877301›Full record

ArticleJournal, genetic engineering & biotechnology2023

Gold nanoparticles combined baker's yeast as a successful approach for breast cancer treatment.

Amany Elwakkad, Amina A Gamal El Din, Hisham A Saleh, Noha E Ibrahim, Mohamed A Hebishy, Hagar H Mourad, Mahitab I El-Kassaby, Howida Sayed Abou-Seif, Ghada M Elqattan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal, genetic engineering & biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Antimicrobial Effect of Silver Nanoparticles Capped withNanomaterials (Basel, Switzerland) · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Amany ElwakkadMedical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt.
Amina A Gamal El DinPathology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt.
Hisham A SalehElectron Microscope and Thin Films Department, Physics Research Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt.
Noha E IbrahimMicrobial Biotechnology Department, Biotechnology Research Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt.
Mohamed A HebishyMedical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt.
Hagar H MouradMedical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt.
Mahitab I El-KassabyMedical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt.
Howida Sayed Abou-SeifMedical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt.
Ghada M ElqattanMedical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt. gm.el-qattan@nrc.sci.eg.ORCID http://orcid.org/0000-0002-3234-8613
National Research Centre · EG

Funding

National Research Centre, Egypt 12060162
6 · The paper itself

Abstract

backgroundSaccharomyces cerevisiae (S. cerevisiae) has been demonstrated in vitro to sensitize several breast cancer cell lines and to be a safe, non-toxic drug with anti-skin cancer action in mice. Furthermore, plasmonic photothermal treatment using gold nanorods has been authorized as a novel method for in vitro and in vivo cancer therapy.

resultsWhen compared to tumor-free rats, the treatment with S. cerevisiae conjugated to gold nanospheres (GNSs) lowered Bcl-2 levels while increasing FasL, Bax, cytochrome c, and caspases 8, 9, and 3 levels. Histopathological results showed changes reflecting the ability of nanogold conjugated heat-killed yeast to induce apoptosis is greater than heat-killed yeast alone as the nanogold conjugated with heat-killed yeast showed no tumor, no hyperplasia, no granulation tissue formation, no ulceration, and no suppuration. Nanogold conjugated with heat-killed yeast-treated breast cancer group displayed normal levels of ALT and AST, indicating relatively healthy hepatic cells.

conclusionOur results proved that nanogold conjugated heat-killed yeast can initiate apoptosis and can be used as a safe non-invasive method for breast cancer treatment more effectively than the yeast alone. This, in turn, gives us new insight and a future hope for the first time that breast cancer can be treated by non-invasive, simple, safe, and naturally originated method and achieves a hopeful treatment and a novel method for in vivo cancer therapy.

Indexed as

ApoptosisBaker’s yeastBreast cancerGold nanospheres

Identifiers

PMID36877301
PMCPMC9989084
OpenAlexW4323294733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.