Evidence map›Paper›PMID 36877298›Full record

ArticleGeroScience2023

Preservation of mitochondrial membrane potential is necessary for lifespan extension from dietary restriction.

Brandon J Berry, Evan Mjelde, Fatima Carreno, Kathryn Gilham, Emily J Hanson, Emily Na, Matt Kaeberlein

Abstract read
In one paragraph

Article in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Changes in the brain [NADFrontiers in aging neuroscience · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. From mitochondria to cells to humans: Targeting bioenergetics in aging and disease.The international journal of biochemistry & cell biology · 2023
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brandon J BerryDepartment of Laboratory Medicine and Pathology, University of Washington Medical Center, 1959 NE Pacific St., Seattle, WA, 98195, USA. bberry5@uw.edu.ORCID 0000-0002-2206-7615
Evan MjeldeDepartment of Laboratory Medicine and Pathology, University of Washington Medical Center, 1959 NE Pacific St., Seattle, WA, 98195, USA.
Fatima CarrenoDepartment of Laboratory Medicine and Pathology, University of Washington Medical Center, 1959 NE Pacific St., Seattle, WA, 98195, USA.
Kathryn GilhamDepartment of Laboratory Medicine and Pathology, University of Washington Medical Center, 1959 NE Pacific St., Seattle, WA, 98195, USA.
Emily J HansonDepartment of Laboratory Medicine and Pathology, University of Washington Medical Center, 1959 NE Pacific St., Seattle, WA, 98195, USA.
Emily NaDepartment of Laboratory Medicine and Pathology, University of Washington Medical Center, 1959 NE Pacific St., Seattle, WA, 98195, USA.
Matt KaeberleinDepartment of Laboratory Medicine and Pathology, University of Washington Medical Center, 1959 NE Pacific St., Seattle, WA, 98195, USA. kaeber@uw.edu.ORCID 0000-0002-1311-3421

Funding

University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Maitreya J Dunham · 1995 to 2026
$27.1M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Biological Mechanisms of Healthy Aging Training GrantT32AG066574 · NIA · UNIVERSITY OF WASHINGTON · PI David J. Marcinek, Jessica E Young · 2020 to 2026
$5.3M
NIA NIH HHS P30 AG013280NIA NIH HHS T32 AG066574NIH HHS P40 OD010440
6 · The paper itself

Abstract

Dietary restriction (DR) increases lifespan in many organisms, but its underlying mechanisms are not fully understood. Mitochondria play a central role in metabolic regulation and are known to undergo changes in structure and function in response to DR. Mitochondrial membrane potential (Δψ

Indexed as

Caenorhabditis elegans ProteinsAdenosine TriphosphateAnimalsCaenorhabditis elegansCaloric RestrictionLongevityMembrane Potential, MitochondrialAdenosine TriphosphateCaenorhabditis elegans ProteinsAgingBioenergeticsCalorie restrictionFastingMetabolismMitochondrial uncoupling

Identifiers

PMID36877298
PMCPMC10400507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.