Evidence map›Paper›PMID 36877189›Full record

ArticleInhalation toxicology

Altered long non-coding RNAs expression in normal and diseased primary human airway epithelial cells exposed to diesel exhaust particles.

C M Sabbir Ahmed, Alexa Canchola, Biplab Paul, Md Rubaiat Nurul Alam, Ying-Hsuan Lin

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inhalation toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

C M Sabbir AhmedEnvironmental Toxicology Graduate Program, University of California, Riverside, CA, USA.ORCID 0000-0002-7254-2955
Alexa CancholaEnvironmental Toxicology Graduate Program, University of California, Riverside, CA, USA.ORCID 0000-0001-8285-4795
Biplab PaulGastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA.
Md Rubaiat Nurul AlamEnvironmental Toxicology Graduate Program, University of California, Riverside, CA, USA.
Ying-Hsuan LinEnvironmental Toxicology Graduate Program, University of California, Riverside, CA, USA.ORCID 0000-0001-8904-1287

Funding

Research Training in Environmental ToxicologyT32ES018827 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2010 to 2026
$5.3M
NIEHS NIH HHS T32 ES018827
6 · The paper itself

Abstract

backgroundExposure to diesel exhaust particles (DEP) has been linked to a variety of adverse health effects, including increased morbidity and mortality from cardiovascular diseases, chronic obstructive pulmonary disease (COPD), metabolic syndrome, and lung cancer. The epigenetic changes caused by air pollution have been associated with increased health risks. However, the exact molecular mechanisms underlying the lncRNA-mediated pathogenesis induced by DEP exposure have not been revealed.

methodsThrough RNA-sequencing and integrative analysis of both mRNA and lncRNA profiles, this study investigated the role of lncRNAs in altered gene expression in healthy and diseased human primary epithelial cells (NHBE and DHBE-COPD) exposed to DEP at a dose of 30 μg/cm

resultsWe identified 503 and 563 differentially expressed (DE) mRNAs and a total of 10 and 14 DE lncRNAs in NHBE and DHBE-COPD cells exposed to DEP, respectively. In both NHBE and DHBE-COPD cells, enriched cancer-related pathways were identified at mRNA level, and 3 common lncRNAs

conclusionsOverall, our work highlights the potential importance of lncRNAs in regulating DEP-induced gene expression changes associated with carcinogenesis, and individuals suffering from COPD are likely to be more vulnerable to these environmental triggers.

Indexed as

Pulmonary Disease, Chronic ObstructiveRNA, Long NoncodingEpithelial CellsHumansParticulate MatterVehicle EmissionsParticulate MatterRNA, Long NoncodingVehicle EmissionscarcinogenesisCOPDDiesel exhaust particlelncRNA-mRNA interactionlncRNAssusceptibility

Identifiers

PMID36877189
PMCPMC10424575

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.