Evidence map›Paper›PMID 36876744›Full record

ReviewThe world journal of men's health2023

The British Society for Sexual Medicine Guidelines on Male Adult Testosterone Deficiency, with Statements for Practice.

Geoffrey Hackett, Michael Kirby, Rowland W Rees, T Hugh Jones, Asif Muneer, Mark Livingston, Nick Ossei-Gerning, Janine David, Jeff Foster, Philip A Kalra and 1 more

Open access · diamondAbstract readReview
In one paragraph

Review in The world journal of men's health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 11 institutions in 2 countries.

Geoffrey HackettDepartment of Urology, Spire Hospital, Little Aston, Birmingham, UK.ORCID https://orcid.org/0000-0003-2274-111X
Michael KirbyTrends in Urology and Men's Health, Letchworth, UK.
Rowland W ReesDepartment of Urology, University Hospital Southampton and UCLH, London, UK.ORCID https://orcid.org/0000-0003-3182-0151
T Hugh JonesDepartment of Endocrinology, Barnsley Hospital, Barnsley, UK.ORCID https://orcid.org/0000-0002-9158-8393
Asif MuneerDivision of Surgery and Interventional Science, NIHR Biomedical Research Centre UCLH, London, UK.ORCID https://orcid.org/0000-0003-2958-1614
Mark LivingstonDepartment of Biochemistry, Black Country Pathology Services, Walsall Manor Hospital, Walsall, UK.ORCID https://orcid.org/0000-0001-6878-0769
Nick Ossei-GerningCardiff and Vale NHS Trust, Cardiff, UK.ORCID https://orcid.org/0000-0003-2783-6783
Janine DavidPortway Surgery, Porthcawl, UK.ORCID https://orcid.org/0000-0002-2099-9857
Jeff FosterLeamington Spa, UK.ORCID https://orcid.org/0000-0002-1845-4954
Philip A KalraDepartment of Nephrology, NCA, Salford Royal Hospital, Salford, UK.ORCID https://orcid.org/0000-0001-7652-1572
Sudarshan RamachandranDepartment of Clinical Biochemistry, University Hospitals Birmingham NHS Foundation Trust, Sutton Coldfield, West Midlands, UK.ORCID https://orcid.org/0000-0003-2299-4133
Associated British Ports (United Kingdom) · GBAston University · GBCardiff and Vale University Health Board · GBLeamington Spa Hospital · GBRoyal Hallamshire Hospital · GBSalford Royal Hospital · GBUCL Biomedical Research Centre · GBUniversity College Hospital · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBUniversity of Hertfordshire · GBWalsall Manor Hospital · GB

Funding

British Society for Sexual Medicine
6 · The paper itself

Abstract

Testosterone deficiency (TD) is an increasingly common problem with significant health implications, but its diagnosis and management can be challenging. A multi-disciplinary panel from BSSM reviewed the available literature on TD and provide evidence-based statements for clinical practice. Evidence was derived from Medline, EMBASE and Cochrane searches on hypogonadism, testosterone therapy (T Therapy) and cardiovascular safety from May 2017 to September 2022. This revealed 1,714 articles, including 52 clinical trials and 32 placebo-controlled randomised controlled trials. A total of twenty-five statements are provided, relating to five key areas: screening, diagnosis, initiating T Therapy, benefits and risks of T Therapy, and follow-up. Seven statements are supported by level 1 evidence, eight by level 2, five by level 3, and five by level 4. Recent studies have demonstrated that low levels of testosterone in men are associated with increased risk of incident type 2 diabetes mellitus, worse outcomes in chronic kidney disease and COVID 19 infection with increased all-cause mortality, along with significant quality of life implications. These guidelines should help practitioners to effectively diagnose and manage primary and age-related TD.

Indexed as

Erectile dysfunctionHypogonadismTestosterone deficiencyTestosterone therapy

Identifiers

PMID36876744
PMCPMC10307648
OpenAlexW4322577336

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.