ArticleDevelopment and psychopathology2024
Life stress influences the relationship between sex hormone fluctuation and affective symptoms in peripubertal female adolescents.
Article in Development and psychopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Links between hormonal and pubertal development, and adolescent females' risk for affective symptoms.Psychoneuroendocrinology · 2026Article
- Gendering the Menstrual Cycle in Behavioral Neuroendocrinology.American journal of human biology : the official journal of the Human Biology Council · 2026Review
- Gender, Living Conditions, and Family Support Associated with Depression Status among Adolescents in Semarang, Indonesia.Clinical practice and epidemiology in mental health : CP & EMH · 2026Article
- Menstrual cycle and mental health in adolescents: a developmental neuroendocrine perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Premenstrual dysphoric disorder as a potential predisposing factor for Alzheimer's disease: a review.Frontiers in endocrinology · 2025Review
- Menstrual cycle related depressive symptoms and their diurnal fluctuations - an ambulatory assessment study.BMC women's health · 2024Observational
- Negative life events and depression by gender in the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil).Clinics (Sao Paulo, Brazil) · 2024Article
- Biobehavioral mechanisms underlying testosterone and mood relationships in peripubertal female adolescents.Development and psychopathology · 2023Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Female adolescents have a greatly increased risk of depression starting at puberty, which continues throughout the reproductive lifespan. Sex hormone fluctuation has been highlighted as a key proximal precipitating factor in the development of mood disorders tied to reproductive events; however, hormone-induced affective state change is poorly understood in the pubertal transition. The present study investigated the impact of recent stressful life events on the relationship between sex hormone change and affective symptoms in peripubertal female participants. Thirty-five peripubertal participants (ages 11-14, premenarchal, or within 1 year of menarche) completed an assessment of stressful life events, and provided weekly salivary hormone collections [estrone, testosterone, dehydroepiandrosterone (DHEA)] and mood assessments for 8 weeks. Linear mixed models tested whether stressful life events provided a context in which within-person changes in hormones predicted weekly affective symptoms. Results indicated that exposure to stressful life events proximal to the pubertal transition influenced the directional effects of hormone change on affective symptoms. Specifically, greater affective symptoms were associated with increases in hormones in a high stress context and decreases in hormones in a low stress context. These findings provide support for stress-related hormone sensitivity as a diathesis for precipitating affective symptoms in the presence of pronounced peripubertal hormone flux.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.