ArticleHypertension (Dallas, Tex. : 1979)2023
Circadian Misalignment Impacts the Association of Visceral Adiposity With Elevated Blood Pressure in Adolescents.
Article in Hypertension (Dallas, Tex. : 1979), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Multidimensional association of sleep health with dietary habits and physical activity in adolescents.Sleep health · 2026Article
- Sex-specific longitudinal associations between repeatedly measured movement behaviours and adiposity measures in school-aged children: a compositional data analysis approach.International journal of obesity (2005) · 2026Article
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- Identifying joint association between body fat distribution with high blood pressure among 7 ∼ 17 years using the BKMR model: findings from a cross-sectional study in China.BMC public health · 2025Article
- Association of Chronotype with Hypertension and Metabolic Parameters in Middle-Aged and Older Adults: A Cross-Sectional Study.Nature and science of sleep · 2025Article
- Adolescent obesity and short sleep duration as independent risk factors for hypertension: a population-based cohort study.Journal of human hypertension · 2024Article
- Association of Wearable Device-Measured Step Volume and Variability With Blood Pressure in Older Chinese Adults: Mobile-Based Longitudinal Observational Study.Journal of medical Internet research · 2024Observational
- Sleep Problems and Health Outcomes Among Urban American Indian and Alaska Native Adolescents.JAMA network open · 2024Observational
- Circadian misalignment impacts the association of visceral adiposity with metabolic syndrome in adolescents.Sleep · 2024Article
- Edward O. Bixler, PhD: from the Apollo project and chimpanzees to sleep epidemiology.Sleep advances : a journal of the Sleep Research Society · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAlthough insufficient sleep has been shown to contribute to obesity-related elevated blood pressure, the circadian timing of sleep has emerged as a novel risk factor. We hypothesized that deviations in sleep midpoint, a measure of circadian timing of sleep, modify the association between visceral adiposity and elevated blood pressure in adolescents.
methodsWe studied 303 subjects from the Penn State Child Cohort (16.2±2.2 years; 47.5% female; 21.5% racial/ethnic minority). Actigraphy-measured sleep duration, midpoint, variability, and regularity were calculated across a 7-night period. Visceral adipose tissue (VAT) was measured with dual-energy X-ray absorptiometry. Systolic blood pressure (SBP) and diastolic blood pressure levels were measured in the seated position. Multivariable linear regression models tested sleep midpoint and its regularity as effect modifiers of VAT on SBP/diastolic blood pressure levels, while adjusting for demographic and sleep covariables. These associations were also examined as a function of being in-school or on-break.
resultsSignificant interactions were found between VAT and sleep irregularity, but not sleep midpoint, on SBP (
conclusionsA delayed and an irregular sleep midpoint during school and during free-days, respectively, increase the impact of VAT on elevated blood pressure in adolescents. These data suggest that deviations in the circadian timing of sleep contribute to the increased cardiovascular sequelae associated with obesity and that its distinct metrics require measurement under different entrainment conditions in adolescents.
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