ArticleActa crystallographica. Section D, Structural biology2023
Accelerating crystal structure determination with iterative AlphaFold prediction.
Article in Acta crystallographica. Section D, Structural biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Review
- Toward an Understanding of the Mechanistic Differences Between the Hydroxylating and Desaturating Pyridoxal 5'-Phosphate-Dependent L-Arginine Oxidases.Chembiochem : a European journal of chemical biology · 2026Article
- Show me how it's done: introducing Protocols.Acta crystallographica. Section F, Structural biology communications · 2026Article
- The structural chemistry and biosynthesis of chlorophylls.RSC chemical biology · 2026Review
- Bridging structure and function: artificial intelligence-based modelling of kidney proteins.Nature reviews. Nephrology · 2026Review
- AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network.Nature methods · 2026Article
- Direct Phasing of Protein Crystals with Continuous Iterative Projection Algorithms and Refined Envelope Reconstruction.Biomolecules · 2026Article
- Direct Phasing of Protein Crystals with Hybrid Difference Map Algorithms.Molecules (Basel, Switzerland) · 2026Article
- AlphaFold Protein Structure Database 2025: a redesigned interface and updated structural coverage.Nucleic acids research · 2026Article
- Completion of partial structures using Patterson maps with the CrysFormer machine-learning model.Acta crystallographica. Section D, Structural biology · 2025Article
- NMR in the Age of Modern Biomedical Research and Drug Discovery.Journal of molecular biology · 2025Review
- Molecular mechanism and structural models of protein-mediated copper transfer to the Arabidopsis thaliana ethylene receptor ETR1 at the ER membrane.Scientific reports · 2025Article
- Categorizing prediction modes within low-pLDDT regions of AlphaFold2 structures: near-predictive, pseudostructure and barbed wire.Acta crystallographica. Section D, Structural biology · 2025Article
- Assisting and accelerating NMR assignment with restrained structure prediction.Communications biology · 2025Article
- Article
- Categorizing prediction modes within low-pLDDT regions of AlphaFold2 structures.bioRxiv : the preprint server for biology · 2025Article
- Project automation in CCP4 Cloud: Enabling customization and high-throughput efficiency.Protein science : a publication of the Protein Society · 2025Article
- An outlook on structural biology after AlphaFold: tools, limits and perspectives.FEBS open bio · 2025Review
- Article
- Genetic Algorithm-Enhanced Direct Method in Protein Crystallography.Molecules (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Experimental structure determination can be accelerated with artificial intelligence (AI)-based structure-prediction methods such as AlphaFold. Here, an automatic procedure requiring only sequence information and crystallographic data is presented that uses AlphaFold predictions to produce an electron-density map and a structural model. Iterating through cycles of structure prediction is a key element of this procedure: a predicted model rebuilt in one cycle is used as a template for prediction in the next cycle. This procedure was applied to X-ray data for 215 structures released by the Protein Data Bank in a recent six-month period. In 87% of cases our procedure yielded a model with at least 50% of C
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