GuidelineInternational psychogeriatrics2024
Reduction and prevention of agitation in persons with neurocognitive disorders: an international psychogeriatric association consensus algorithm.
Guideline in International psychogeriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Efficacy and Safety of Cannabinoids for Neuropsychiatric Symptoms of Dementia: A Systematic Review with Meta-analysis.CNS drugs · 2026Pooled it
- Assessment of agitation and aggression in inpatients with alcohol use disorder: A systematic review of informant-based scales.Alcohol, clinical & experimental research · 2025Pooled it
- Sativex (nabiximols) for the treatment of Agitation & Aggression in Alzheimer's dementia in UK nursing homes: a randomised, double-blind, placebo-controlled feasibility trial.Age and ageing · 2025Trial
- Understanding Risks in the Care of People With Dementia in Acute Hospital Settings: Definitions, Types and Management Strategies-A Scoping Review.Journal of clinical nursing · 2026Article
- Toward Precision Neuropsychiatry of Dementia: Neuropsychiatric Symptoms as Multidimensional Clinical Phenotypes.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Review
- Characterizing treatment initiation with central nervous system-active polypharmacy among adults with dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- From schizophrenia to dementia: Is Cobenfy a potential treatment for behavioral and psychological symptoms of dementia?The Journal of international medical research · 2026Article
- Real-World Evidence of Brexpiprazole Use and 6-Month Mortality, Hospitalization, and Emergency Department Visits Among Persons With Dementia.Neurology · 2025Article
- A critical review of brexpiprazole oral tablets as the first drug approved to treat agitation symptoms associated with dementia due to Alzheimer's disease.Expert review of neurotherapeutics · 2025Review
- Efficacy of Sodium Valproate in Behavioral and Psychological Symptoms of Dementia: A Retrospective Observational Study from PUMCH Dementia Cohort.Current Alzheimer research · 2025Observational
- Progress in Pharmacologic Management of Neuropsychiatric Syndromes in Neurodegenerative Disorders: A Review.JAMA neurology · 2024Review
- Challenges and proposed solutions to conducting Alzheimer's disease psychosis trials.Frontiers in psychiatry · 2024Article
- Behavioral or neuropsychiatric symptoms of Alzheimer's disease: from psychopathology to pharmacological management.Arquivos de neuro-psiquiatria · 2023Article
- Characterizing PRN Use of Psychotropic Medications for Acute Agitation in Canadian Long-Term Care Residents with Dementia Before and During COVID-19.Journal of Alzheimer's disease reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 13 institutions in 6 countries.
Funding
Abstract
objectivesTo develop an agitation reduction and prevention algorithm is intended to guide implementation of the definition of agitation developed by the International Psychogeriatric Association (IPA).
designReview of literature on treatment guidelines and recommended algorithms; algorithm development through reiterative integration of research information and expert opinion.
settingIPA Agitation Workgroup.
participantsIPA panel of international experts on agitation.
interventionIntegration of available information into a comprehensive algorithm. MEASUREMENTS: None.
resultsThe IPA Agitation Work Group recommends the Investigate, Plan, and Act (IPA) approach to agitation reduction and prevention. A thorough investigation of the behavior is followed by planning and acting with an emphasis on shared decision-making; the success of the plan is evaluated and adjusted as needed. The process is repeated until agitation is reduced to an acceptable level and prevention of recurrence is optimized. Psychosocial interventions are part of every plan and are continued throughout the process. Pharmacologic interventions are organized into panels of choices for nocturnal/circadian agitation; mild-moderate agitation or agitation with prominent mood features; moderate-severe agitation; and severe agitation with threatened harm to the patient or others. Therapeutic alternatives are presented for each panel. The occurrence of agitation in a variety of venues-home, nursing home, emergency department, hospice-and adjustments to the therapeutic approach are presented.
conclusionsThe IPA definition of agitation is operationalized into an agitation management algorithm that emphasizes the integration of psychosocial and pharmacologic interventions, reiterative assessment of response to treatment, adjustment of therapeutic approaches to reflect the clinical situation, and shared decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.