Evidence map›Paper›PMID 36876222›Full record

ArticleJID innovations : skin science from molecules to population health2023

Modulation of Inflammatory Proteins in Serum May Reflect Cutaneous Immune Responses in Cancer Immunotherapy.

Joseph Han, Joel Correa da Rosa, Aneesh Agarwal, Shayan Owji, Daniel Yassky, Yen Luu, Aatman Shah, Yeriel Estrada, Jonathan Ungar, Kavita Y Sarin and 2 more

Open access · goldAbstract read
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Joseph HanDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Joel Correa da RosaDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Aneesh AgarwalDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Shayan OwjiDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Daniel YasskyDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Yen LuuSchool of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Aatman ShahDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Yeriel EstradaDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jonathan UngarDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kavita Y SarinDepartment of Dermatology, Stanford University School of Medicine, Stanford, California, USA.
James G KruegerLaboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA.
Nicholas GulatiDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Icahn School of Medicine at Mount Sinai · USRockefeller University · USStanford University · USUniversity of Missouri–Kansas City · US

Funding

Skin Biology and Diseases Resource-based Center at Mount SinaiP30AR079200 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elena Ezhkova · 2021 to 2026
$5.2M
NIAMS NIH HHS P30 AR079200
6 · The paper itself

Abstract

Diphencyprone (DPCP), a topical contact sensitizer, has shown efficacy in treating cutaneous melanoma metastases, including at times beyond the directly treated sites, but biomarkers indicative of treatment response have not been characterized. Thus, we performed a proteomic analysis of the skin and serum of five patients with cutaneous melanoma metastases treated with DPCP on days 0, 63, and 112 of the treatment course. In the serum, we found a significant upregulation (

Indexed as

DPCP, diphencyproneICI, immune checkpoint inhibitorTh, T helper

Identifiers

PMID36876222
PMCPMC9982329
OpenAlexW4318320784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.