Evidence map›Paper›PMID 36876221›Full record

ReviewJID innovations : skin science from molecules to population health2023

Dermatologic Manifestations of Noninflammasome-Mediated Autoinflammatory Diseases.

Dörte Symmank, Carina Borst, Mathias Drach, Wolfgang Weninger

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JID innovations : skin science from molecules to population health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dörte SymmankDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Carina BorstDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Mathias DrachDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Wolfgang WeningerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoinflammatory diseases (AIDs) arise from disturbances that alter interactions of immune cells and tissues. They give rise to prominent (auto)inflammation in the absence of aberrant autoantibodies and/or autoreactive T cells. AIDs that are predominantly caused by changes in the inflammasome pathways, such as the NLRP3- or pyrin-associated inflammasome, have gained substantial attention over the last years. However, AIDs resulting primarily from other changes in the defense system of the innate immune system are less well-studied. These noninflammasome-mediated AIDs relate to, for example, disturbance in the TNF or IFN signaling pathways or aberrations in genes affecting the IL-1RA. The spectrum of clinical signs and symptoms of these conditions is vast. Thus, recognizing early cutaneous signs constitutes an important step in differential diagnoses for dermatologists and other physicians. This review provides an overview of the pathogenesis, clinical presentation, and available treatment options highlighting dermatologic aspects of noninflammasome-mediated AIDs.

Indexed as

AID, autoinflammatory diseaseANCA, antineutrophil cytoplasmic antibodyAOSD, adult-onset Still diseaseBASDAI, Bath Ankylosing Spondylitis Activity IndexCANDLE, chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatureCAPS, cryopyrin-associated periodic syndromeCRD, cysteine-rich domainDIRA, deficiency of IL-1RADITRA, deficiency of IL-36RAER, endoplasmic reticulumESR, erythrocyte sedimentation rateFMF, familial Mediterranean feverMAS, macrophage activation syndromeM-CSF, macrophage colony-stimulating factorNET, neutrophil extracellular trapNOS, nitrous oxideNSAID, nonsteroidal anti-inflammatory drugNUD, neutrophilic urticarial dermatosisPFAPA, periodic fever, aphthous stomatitis, pharyngitis, and adenitisPKR, protein kinase RPRAAS, proteosome-associated autoinflammatory diseaseSAPHO, synovitis, acne, pustulosis, hyperostosis, osteitis syndromeSAVI, STING-associated vasculopathy with onset in infancySchS, Schnitzler syndromeSTAT, signal transducer and activator of transcriptionsTNFR, soluble TNF receptorTh17, T helper 17TNFR, TNF receptorTRAPS, TNF receptor‒associated autoinflammatory diseaseVAS, Visual Analog Scale

Identifiers

PMID36876221
PMCPMC9982332
OpenAlexW4311751084

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.