ArticleFrontiers in microbiology2023
Endogenous relapse and exogenous reinfection in recurrent pulmonary tuberculosis: A retrospective study revealed by whole genome sequencing.
Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 15 citations in OpenAlex.
- Long term outcomes in drug resistant tuberculosis with Bedaquiline, Pretomanid and varying doses of Linezolid.The Journal of infection · 2025Trial
- Key impact of Beijing strains including new resistant clusters on spread of multidrug-resistant tuberculosis in northern Russia.Microbiology spectrum · 2026Article
- Comparison of characteristics of drug-resistantJournal of family medicine and primary care · 2026Article
- Epidemiological analysis and risk factors of recurrent pulmonary tuberculosis in Western Zhejiang Province, China (2007-2024).Frontiers in public health · 2026Article
- Prevalence of Drug-Resistant Mycobacterium tuberculosis in Rural Communities of Vhembe District, South Africa.Advances in experimental medicine and biology · 2026Article
- Uncovering the burden of tuberculosis in Algeria: a retrospective analysis from 2019 to 2024.Antonie van Leeuwenhoek · 2025Article
- Characterizing the Etiology of Recurrent Tuberculosis Using Whole Genome Sequencing: Alaska, 2008-2020.The Journal of infectious diseases · 2025Article
- Endogenous reactivation cases identified by whole genome sequencing ofJournal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Timing of recurrence after treatment of pulmonary TB.IJTLD open · 2024Article
- Antibiotic treatment modestly reduces protection againstInfection and immunity · 2024Article
- Antibiotic treatment modestly reduces protection against Mycobacterium tuberculosis reinfection in macaques.bioRxiv : the preprint server for biology · 2024Article
- Article
- Advancing tuberculosis management: the role of predictive, preventive, and personalized medicine.Frontiers in microbiology · 2023Review
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Authors and funding
18 authors at 6 institutions in 1 country.
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Abstract
Background: Tuberculosis may reoccur due to reinfection or relapse after initially successful treatment. Distinguishing the cause of TB recurrence is crucial to guide TB control and treatment. This study aimed to investigate the source of TB recurrence and risk factors related to relapse in Hunan province, a high TB burden region in southern China. Methods: A population-based retrospective study was conducted on all culture-positive TB cases in Hunan province, China from 2013 to 2020. Phenotypic drug susceptibility testing and whole-genome sequencing were used to detect drug resistance and distinguish between relapse and reinfection. Pearson chi-square test and Fisher exact test were applied to compare differences in categorical variables between relapse and reinfection. The Kaplan-Meier curve was generated in R studio (4.0.4) to describe and compare the time to recurrence between different groups. Results: Of 36 recurrent events, 27 (75.0%, 27/36) paired isolates were caused by relapse, and reinfection accounted for 25.0% (9/36) of recurrent cases. No significant difference in characteristics was observed between relapse and reinfection (all Conclusion: Endogenous relapse is the main mechanism leading to TB recurrences in Hunan province. Given that TB recurrences can occur more than 4 years after treatment completion, it is necessary to extend the post-treatment follow-up period to achieve better management of TB patients. Moreover, the relatively high frequency of fluoroquinolone resistance in the second episode of relapse suggests that fluoroquinolones should be used with caution when treating TB cases with relapse, preferably guided by DST results.
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