Evidence map›Paper›PMID 36875937›Full record

RevieweNeurologicalSci2023

A meta-analysis of post-exercise outcomes in people with amyotrophic lateral sclerosis.

Cara Donohue, Giselle Carnaby, Mary Catherine Reilly, Ryan J Colquhoun, David Lacomis, Kendrea L Focht Garand

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in eNeurologicalSci, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Cara DonohueDepartment of Communication Science and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Giselle CarnabyDepartment of Health Sciences, School of Health Professions, University of Texas Health Science Center, San Antonio, TX 77030, USA.
Mary Catherine ReillyDepartment of Speech Pathology and Audiology, College of Allied Health Professions, University of South Alabama, Mobile, AL 36688, USA.
Ryan J ColquhounDepartment of Health, Kinesiology, and Sport, College of Education and Professional Studies, University of South Alabama, Mobile, AL 36688, USA.
David LacomisDepartments of Neurology and Pathology and the Live Like Lou Center for ALS Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Kendrea L Focht GarandDepartment of Communication Science and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
University of Pittsburgh · USUniversity of South Alabama · USThe University of Texas Health Science Center at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To systematically evaluate post-exercise outcomes related to function and quality of life in people with ALS. Methods: PRISMA guidelines were used for identifying and extracting articles. Levels of evidence and quality of articles were judged based on Results: 16 studies and seven functional outcomes met inclusion for the meta-analysis. Of the outcomes explored, the ALSFRS-R demonstrated a favorable summary effect size and had acceptable heterogeneity and dispersion. While FIM scores demonstrated a favorable summary effect size, heterogeneity limited interpretations. Other outcomes did not demonstrate a favorable summary effect size and/or could not be reported due to few studies reporting outcomes. Conclusions: This study provides inconclusive guidance regarding exercise regimens to maintain function and quality of life in people with ALS due to study limitations (e.g., small sample size, high attrition rate, heterogeneity in methods and participants, etc.). Future research is warranted to determine optimal treatment regimens and dosage parameters in this patient population.

Indexed as

25FWT, (25 Feet Walk Test)6MWT, (6 Minute Walk Test)ALS, (amyotrophic lateral sclerosis)ALSFRS-R, (ALS Functional Rating Scale-Revised)Amyotrophic lateral sclerosisDIGEST, (Dynamic Imaging Grade of Swallowing Toxicity)EAT-10, (Eating Assessment Tool)EMST, (Expiratory muscle strength training)ExerciseFAC, (Functional Ambulation Categories)FIM, (Functional Independence Measurement)FOIS, (Functional Oral Intake Scale)FSS, (Fatigue Severity Scale)FVC, (forced vital capacity)IMST, (Inspiratory muscle strength training)ITT, (intention-to-treat)KEMS, (knee extension muscle strength)MEP, (maximum expiratory pressure)MIP, (maximum inspiratory pressure)MND, (motor neuron disease)Motor neuron diseaseMVIC, (maximum voluntary isometric contraction)Outcome measuresPAS, (Penetration Aspiration Scale)PEF, (peak expiratory flow)PRISMA-2009, (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)RCTs, (randomized controlled trials)RehabilitationRPE, (rating of perceived exertion)SNIP, (sniff nasal inspiratory pressure)

Identifiers

PMID36875937
PMCPMC9982645
OpenAlexW4321460279

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.