Evidence map›Paper›PMID 36875922›Full record

ArticlePlastic and reconstructive surgery. Global open2023

Immunohistochemical Analysis of Lymphocyte Populations in Acute Skin Rejection: The University Health Network Addition to the Banff Classification.

Siba Haykal, Natasha Barone, Sara Rostami, Sajad Moshkelgosha, Stephen Juvet, Shaf Keshavjee, Danny Ghazarian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siba HaykalLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.
Natasha BaroneFaculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.
Sara RostamiLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.
Sajad MoshkelgoshaLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.
Stephen JuvetLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.
Shaf KeshavjeeLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.
Danny GhazarianDepartment of Pathology, University Health Network, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute rejection in vascularized composite allotransplantation has been identified using the Banff 2007 working classification. We propose an addition to this classification based on histological and immunological assessment within the skin and subcutaneous tissue. Methods: Biopsies from vascularized composite transplant patients were obtained at scheduled visits and whenever skin changes occurred. Histology and immunohistochemistry were performed on all samples, looking at infiltrating cells. Results: Observations were made specifically related to each component of the skin, including the epidermis, dermis, vessels, and subcutaneous tissue. Our findings led to the establishment of the University Health Network addition of skin rejection. Conclusions: The high rate of rejection where the skin is involved requires novel techniques for early detection. The University Health Network skin rejection addition can serve as an adjunct to the Banff classification.

Identifiers

PMID36875922
PMCPMC9984153

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.