Evidence map›Paper›PMID 36875910›Full record

ReviewJACC. CardioOncology2023

Screening for Coronary Artery Disease in Cancer Survivors:

Ragani Velusamy, Mark Nolan, Andrew Murphy, Paaladinesh Thavendiranathan, Thomas H Marwick

Open access · goldAbstract readReview
In one paragraph

Review in JACC. CardioOncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ragani VelusamyBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Mark NolanBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Andrew MurphyBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Paaladinesh ThavendiranathanTed Rogers Program in Cardiotoxicity Prevention, Peter Munk Cardiac Center, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Thomas H MarwickBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Baker Heart and Diabetes Institute · AUToronto General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary artery disease (CAD) is an important contributor to the cardiovascular burden in cancer survivors. This review identifies features that could help guide decisions about the benefit of screening to assess the risk or presence of subclinical CAD. Screening may be appropriate in selected survivors based on risk factors and inflammatory burden. In cancer survivors who have undergone genetic testing, polygenic risk scores and clonal hematopoiesis markers may become useful CAD risk prediction tools in the future. The type of cancer (especially breast, hematological, gastrointestinal, and genitourinary) and the nature of treatment (radiotherapy, platinum agents, fluorouracil, hormonal therapy, tyrosine kinase inhibitors, endothelial growth factor inhibitors, and immune checkpoint inhibitors) are also important in determining risk. Therapeutic implications of positive screening include lifestyle and atherosclerosis interventions, and in specific instances, revascularization may be indicated.

Indexed as

ACS, acute coronary syndromeAYA, adolescent and young adultCAC, coronary artery calciumCAD, coronary artery diseasecalcificationCHIP, clonal hematopoiesis of indeterminate potentialCMR, cardiac magnetic resonancecoronary artery calciumcoronary artery diseaseCTA, computed tomography angiographyCVD, cardiovascular diseaseIGF, insulin-like growth factorLDL, low-density lipoproteinPCE, pooled cohort equationsPCI, percutaneous coronary interventionpreventionPRS, polygenic risk scorerisk factorrisk predictionROS, reactive oxygen speciesTKI, tyrosine kinase inhibitorVEGF, vascular endothelial growth factor

Identifiers

PMID36875910
PMCPMC9982229
OpenAlexW4321503097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.