ArticleJACC. CardioOncology2023
Association of Midlife Cardiovascular Health and Subsequent Change in Cardiovascular Health With Incident Cancer.
Article in JACC. CardioOncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- American Heart Association cardiovascular health metrics and cancer outcomes: A systematic review and meta-analysis.American heart journal · 2026Pooled it
- Association of Life's Essential 8 Score With Incident Pancreatic Cancer: A Prospective Cohort Study in Shanghai, China.Cancer science · 2026Article
- Aging and increased cancer risk: exploring the potential of LE8 score to mitigate risk.npj aging · 2026Article
- Impact of Smoking Status on Major Adverse Cardiovascular Events in STEMI Patients: A Retrospective Cohort Study in Western Iran.ARYA atherosclerosis · 2026Article
- The Growing Intersection Between Cancer and Cardiovascular Disease.JACC. CardioOncology · 2025Article
- Cardiovascular Risk, Health Metrics, and Cancer Prediction: A Scoping Review.JACC. CardioOncology · 2025Article
- Life's essential 8 and specific cancer risk and mortality in men and women: a population-based cohort analysis of 332,417 United Kingdom participants.BMC cancer · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Cardiovascular Health Status in US Adults With Chronic Diseases: National Health and Nutrition Examination Survey (NHANES), 2013-2018.Journal of the American Heart Association · 2025Article
- Associations of Neighborhood Food and Physical Activity Environments in Young Adulthood With Cardiovascular Health in Midlife: The CARDIA Study.Journal of the American Heart Association · 2024Article
- Novel Multicomponent Digital Care Assistant and Support Program for People After Stroke or Transient Ischaemic Attack: A Pilot Feasibility Study.Sensors (Basel, Switzerland) · 2024Article
- Cardiovascular health and cancer mortality: evidence from US NHANES and UK Biobank cohort studies.BMC medicine · 2024Article
- Cardiovascular disease and cancer: shared risk factors and mechanisms.Nature reviews. Cardiology · 2024Review
- Association between changes in cardiovascular health and the risk of multimorbidity: community-based cohort studies in the UK and Finland.The Lancet regional health. Europe · 2024Article
- Article
- Achieving Optimal Cardiovascular Health: A Way to Help Prevent Cancer?JACC. CardioOncology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The commonality of risk factors between cancer and cardiovascular disease suggests that primordial prevention (preventing the onset of risk factors) is a relevant strategy for cancer prevention. Objectives: This study sought to examine the association between baseline and change in the cardiovascular health (CVH) score and incident cancer. Methods: Using serial examinations of the GAZEL (GAZ et ELECTRICITE de France) study in France, we examined the associations between the American Heart Association's Life's Simple 7 CVH score (range: 0-to 14 [poor, intermediate, and ideal level of smoking, physical activity, body mass index, diet, blood pressure, diabetes status, or lipids]) in 1989/1990, their change over 7 years, and incident cancer and cardiac events up to 2015. Results: The study population included 13,933 participants (mean age: 45.3 ± 3.4 years, 24% women). After a median follow-up of 24.8 years (Q1-Q3: 19.4-24.9 years), 2,010 participants had an incident cancer and 899 a cardiac event. The risk of cancer (any site) decreased by 9% (HR: 0.91; 95% CI: 0.88-0.93) per 1-point increase in the CVH score in 1989/1990 compared with a 20% (HR: 0.80; 95% CI: 0.77-0.83) risk reduction for cardiac events. The risk of cancer decreased by 5% (HR: 0.95; 95% CI: 0.92-0.99) per unit of change in the CVH score between 1989/1990 and 1996/1997 compared with a 7% risk reduction for cardiac events (HR: 0.93; 95% CI: 0.88-0.98). These associations remained after omitting the smoking metric from the CVH score. Conclusions: Primordial prevention is a relevant strategy for the prevention of cancer in the population.
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