Evidence map›Paper›PMID 36875891›Full record

ArticleImmunoinformatics (Amsterdam, Netherlands)2023

Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings.

Runpeng Li, Prativa Sahoo, Dongrui Wang, Qixuan Wang, Christine E Brown, Russell C Rockne, Heyrim Cho

Open access · goldAbstract read
In one paragraph

Article in Immunoinformatics (Amsterdam, Netherlands), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  4. Physiologically based pharmacokinetic model for CAR-T cell delivery and efficacy in solid tumors.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Runpeng LiDepartment of Mathematics, University of California Riverside, 900 University Ave., Riverside, 92521, CA, USA.
Prativa SahooDivision of Mathematical Oncology, Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, 91010, CA, USA.
Dongrui WangZhejiang University Medical Center, 866 Yuhangtang Rd, Hangzhou, 310058, PR China.
Qixuan WangDepartment of Mathematics, University of California Riverside, 900 University Ave., Riverside, 92521, CA, USA.
Christine E BrownDepartment of Hematology & Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, 91010, CA, USA.
Russell C RockneDivision of Mathematical Oncology, Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, 91010, CA, USA.
Heyrim ChoDepartment of Mathematics, University of California Riverside, 900 University Ave., Riverside, 92521, CA, USA.
City Of Hope National Medical Center · USUniversity of California, Riverside · USZhejiang University · CN

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
Clinical evaluation of IL13Ra2-targeted CAR T cell therapy in combination with nivolumab in patients with recurrent malignant gliomaR01CA236500 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BADIE, BEHNAM, BROWN, CHRISTINE · 2019 to 2024
$3.3M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA236500
6 · The paper itself

Abstract

Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in treating blood cancers, and its application to solid tumors is currently being extensively investigated. For glioma brain tumors, various CAR T-cell targets include IL13R

Indexed as

Adoptive cell therapyChimeric antigen receptor T-cellDynamical systemImmunotherapyMathematical Oncology

Identifiers

PMID36875891
PMCPMC9983577
OpenAlexW4320168301

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.