ArticleBiochemistry and biophysics reports2023
New perspective for an old drug: Can naloxone be considered an antioxidant agent?
Article in Biochemistry and biophysics reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 5 citations in OpenAlex.
- Antioxidant Activity and Cytotoxicity Evaluation of New Catechol Hydrazinyl-Thiazole Derivatives as Potential Protectors in Retinal Degenerative Processes.Antioxidants (Basel, Switzerland) · 2025Article
- In Vitro Effects of Fentanyl on Aortic Viscoelasticity in a Rat Model of Melatonin Deficiency.International journal of molecular sciences · 2024Article
- Probing the Therapeutic Efficacy ofBioinformatics and biology insights · 2024Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
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Abstract
Background: Experimental evidence indicates that Naloxone (NLX) holds antioxidant properties. The present study aims at verifying the hypothesis that NLX could prevent oxidative stress induced by hydrogen peroxide (H Methods: To investigate the antioxidant effect of NLX, initially, we performed electrochemical experiments by means of platinum-based sensors in a cell-free system. Subsequently, NLX was tested in PC12 cells on H Results: This study reveals that NLX counteracts intracellular ROS production, reduces H Conclusion: Overall, these findings provide a starting point for studying further the protective effects of NLX on oxidative stress.
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