Evidence map›Paper›PMID 36875757›Full record

ArticleFrontiers in cell and developmental biology2023

Prostaglandins limit nuclear actin to control nucleolar function during oogenesis.

Danielle E Talbot, Bailey J Vormezeele, Garrett C Kimble, Dylane M Wineland, Daniel J Kelpsch, Michelle S Giedt, Tina L Tootle

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Nucleolar Dynamics During Oogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  2. Recent advances in nuclear actin research.Nucleus (Austin, Tex.) · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Nuclear actin is a critical regulator ofbioRxiv : the preprint server for biology · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Danielle E TalbotAnatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States.
Bailey J VormezeeleAnatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States.
Garrett C KimbleAnatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States.
Dylane M WinelandAnatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States.
Daniel J KelpschAnatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States.
Michelle S GiedtAnatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States.
Tina L TootleAnatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States.
University of Iowa · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
TRAINING PROGRAM IN FREE RADICAL AND RADIATION BIOLOGYT32CA078586 · NCI · UNIVERSITY OF IOWA · PI SPITZ, DOUGLAS ROBERT · 1999 to 2024
$5.7M
Prostaglandins control development by coordinating actin cytoskeletal remodelingR01GM116885 · NIGMS · UNIVERSITY OF IOWA · PI TOOTLE, TINA L · 2016 to 2020
$1.6M
NCI NIH HHS T32 CA078586NIGMS NIH HHS R01 GM116885NIH HHS P40 OD018537
6 · The paper itself

Abstract

Prostaglandins (PGs), locally acting lipid signals, regulate female reproduction, including oocyte development. However, the cellular mechanisms of PG action remain largely unknown. One cellular target of PG signaling is the nucleolus. Indeed, across organisms, loss of PGs results in misshapen nucleoli, and changes in nucleolar morphology are indicative of altered nucleolar function. A key role of the nucleolus is to transcribe ribosomal RNA (rRNA) to drive ribosomal biogenesis. Here we take advantage of the robust,

Indexed as

Drosophila prostaglandins limit nucleolar functionnuclear actinnucleolusoogenesisprostaglandins

Identifiers

PMID36875757
PMCPMC9981675
OpenAlexW4321238197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.