Evidence map›Paper›PMID 36875739›Full record

ArticleAPL bioengineering2023

Model of collective detachment in high-grade serous ovarian cancer demonstrates that tumor spheroids produce ECM to support metastatic processes.

Hannah M Micek, Lauren Rosenstock, Yicheng Ma, Caitlin Hielsberg, Lauren Montemorano, Metti K Gari, Suzanne M Ponik, Pamela K Kreeger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hannah M MicekDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.ORCID https://orcid.org/0000-0001-7395-8250
Lauren RosenstockDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.ORCID https://orcid.org/0000-0002-8206-5566
Yicheng MaDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.ORCID https://orcid.org/0000-0002-7392-3274
Caitlin HielsbergDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.ORCID https://orcid.org/0000-0002-9247-6019
Lauren MontemoranoDepartment of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA.ORCID https://orcid.org/0000-0002-8724-6622
Metti K GariORCID https://orcid.org/0000-0002-6381-3696
Suzanne M PonikORCID https://orcid.org/0000-0003-1367-4349
Pamela K KreegerORCID https://orcid.org/0000-0001-8193-1007
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
The role of multi-cellular aggregates vs. individual tumor cells in metastasis of high-grade serous ovarian cancerR01CA240965 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KREEGER, PAMELA K · 2020 to 2025
$2.7M
Engineered ECM platforms to analyze progression in high grade serous ovarian cancerR01CA232517 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAMPAGNOLA, PAUL J, KREEGER, PAMELA K · 2018 to 2022
$2.4M
Direct therapeutic intervention of the tumor microenvironment with a potent inhibitor of fibronectin assemblyR21CA252579 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KWON, GLEN S., PONIK, SUZANNE MARIE · 2021 to 2022
$386k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA232517NCI NIH HHS R01 CA240965NCI NIH HHS R21 CA252579
6 · The paper itself

Abstract

High-grade serous ovarian cancer (HGSOC) metastasizes through transcoelomic spread, with both single cells and spheroids of tumor cells observed in patient ascites. These spheroids may form through single cells that detach and aggregate (Sph-SC) or through collective detachment (Sph-CD). We developed an

Identifiers

PMID36875739
PMCPMC9977464
OpenAlexW4322627666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.