ReviewCancer diagnosis & prognosis
An Update on Clinicopathological, Imaging, and Genetic Features of Angioleiomyoma.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- MRI findings for differentiating benign and malignant soft tissue tumors: a systematic review-part 2: key imaging findings.Skeletal radiology · 2026Pooled it
- Plantar Angioleiomyoma Masquerading as a Hyperkeratotic Lesion: A Case Report.Clinical case reports · 2026Article
- Soft tissue reporting and data system (soft tissue-RADS): framework for radiologists specializing in imaging of musculoskeletal tumors and tumor-like lesions.Skeletal radiology · 2026Review
- A rare case of deep-seated angioleiomyoma causing fixed flexion contracture of the knee: a case report.International journal of surgery case reports · 2026Article
- Cervical angioleiomyoma: A rare tumor behind persistent menorrhagia and pelvic pain.Oncoscience · 2026Article
- Clinical and pathological characteristics, diagnosis, and surgical treatment of uterine angioleiomyoma: a retrospective cohort study.Frontiers in medicine · 2026Article
- Unusual solid submucosal angioleiomyoma of the upper lip: A case report and review of the literature.Medicine · 2025Review
- Robot-assisted inferior mediastinal angioleiomyoma resection with diagonal approach.JTCVS techniques · 2025Article
- Article
- Uterine Angioleiomyoma: Clinical and Histopathologic Differentiation of an Underrecognized Mimicker of Uterine Leiomyoma.International journal of surgical pathology · 2025Article
- Pitfalls in Ultrasound Diagnosis of Vascular Malformations: A Retrospective Review of 14 Nonvascular Tumors Treated as Vascular Malformations.Diagnostics (Basel, Switzerland) · 2025Article
- Ultrasound and magnetic resonance imaging (MRI) features of angioleiomyoma.Quantitative imaging in medicine and surgery · 2024Article
- Clinical characteristics and treatment outcomes of angioleiomyoma of the female genital tract: a retrospective cohort study.BMC women's health · 2024Article
- Discovering an uncommon site of angioleiomyoma origin: a rare case report.Annals of medicine and surgery (2012) · 2024Article
- Angioleiomyoma: An Update with a 142-Case Series.Life (Basel, Switzerland) · 2024Article
- Perirectal angioleiomyoma preoperatively misdiagnosed as rectal cancer: a case report.Frontiers in oncology · 2024Article
- A Rare Case of Angioleiomyoma of the Palm.Journal of the Belgian Society of Radiology · 2024Article
- Angioleiomyoma of cheek - A case report highlighting immunohistochemical diagnostic approach.Journal of oral and maxillofacial pathology : JOMFPArticle
- Endobronchial angioleiomyoma: Diagnostic difficulties of a rare lung neoplasm.Annals of thoracic medicineArticle
- Acral Angioleiomyoma With Tumoral Calcinosis: A Rare Case Report and Literature Review.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angioleiomyoma is a benign, pericytic (perivascular) neoplasm that primarily occurs in the subcutis or dermis of the extremities. The lesion typically presents as a small, firm, slow-growing, painful nodule. Magnetic resonance imaging reveals the lesion to be a well-defined, round to oval mass with signal intensity similar to or slightly hyperintense to that of skeletal muscle on T1-weightwed sequences. A dark reticular sign on T2-weighted sequences appears to be a characteristic feature of angioleiomyoma. Prominent enhancement is usually seen after intravenous contrast. Histologically, the lesion consists of well-differentiated smooth muscle cells with many vascular channels. Based on vascular morphologies, angioleiomyoma is classified into three subtypes: solid, venous, and cavernous. By immunohistochemistry, angioleiomyoma is diffusely positive for smooth muscle actin and calponin and variably for h-caldesmon and desmin. Conventional cytogenetic studies have demonstrated relatively simple karyotypes characterized by one or few structural rearrangements or numerical aberrations. In addition, metaphase comparative genomic hybridization analyses have revealed recurrent loss of 22q and gain of Xq. Angioleiomyoma can be successfully treated with simple excision, with a very low recurrence rate. Knowledge of this peculiar neoplasm is important because it can mimic a variety of benign and malignant soft-tissue tumors. This review provides an updated overview of the clinical, radiological, histopathological, cytogenetic, and molecular genetic features of angioleiomyoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.