Evidence map›Paper›PMID 36875144›Full record

ReviewFrontiers in immunology2023

Capturing the multifaceted function of adipose tissue macrophages.

Alyssa J Matz, Lili Qu, Keaton Karlinsey, Anthony T Vella, Beiyan Zhou

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alyssa J MatzDepartment of Immunology, School of Medicine, University of Connecticut, Farmington, CT, United States.
Lili QuDepartment of Immunology, School of Medicine, University of Connecticut, Farmington, CT, United States.
Keaton KarlinseyDepartment of Immunology, School of Medicine, University of Connecticut, Farmington, CT, United States.
Anthony T VellaDepartment of Immunology, School of Medicine, University of Connecticut, Farmington, CT, United States.
Beiyan ZhouDepartment of Immunology, School of Medicine, University of Connecticut, Farmington, CT, United States.

Funding

MiR-150 regulated adiose tissue B cells in obesityR01DK121805 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI VELLA, ANTHONY T, ZHOU, BEIYAN · 2020 to 2024
$2.0M
NIDDK NIH HHS R01 DK121805
6 · The paper itself

Abstract

Adipose tissue macrophages (ATMs) bolster obesity-induced metabolic dysfunction and represent a targetable population to lessen obesity-associated health risks. However, ATMs also facilitate adipose tissue function through multiple actions, including adipocyte clearance, lipid scavenging and metabolism, extracellular remodeling, and supporting angiogenesis and adipogenesis. Thus, high-resolution methods are needed to capture macrophages' dynamic and multifaceted functions in adipose tissue. Herein, we review current knowledge on regulatory networks critical to macrophage plasticity and their multifaceted response in the complex adipose tissue microenvironment.

Indexed as

AdipocytesAdipose TissueAdipogenesisHumansMacrophagesObesityadipose tissueimmune responsemacrophageobesitysingle-cell RNA sequencing

Identifiers

PMID36875144
PMCPMC9977801

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.