Evidence map›Paper›PMID 36875021›Full record

ArticleFrontiers in physiology2023

Using carpet plots to analyze blood transit times in the brain during hypercapnic challenge magnetic resonance imaging.

Bradley Fitzgerald, Jinxia Fiona Yao, Lia M Hocke, Blaise deB Frederick, Christiaan Hendrik Bas van Niftrik, Yunjie Tong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Cerebrovascular reactivity delay measured by blood oxygen level dependent magnetic resonance imaging and gas challenges: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Bradley FitzgeraldElmore Family School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States.
Jinxia Fiona YaoWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States.
Lia M HockeMcLean Imaging Center, McLean Hospital, Belmont, MA, United States.
Blaise deB FrederickMcLean Imaging Center, McLean Hospital, Belmont, MA, United States.
Christiaan Hendrik Bas van NiftrikDepartment of Neurosurgery, University Hospital Zurich, Zurich, Switzerland.
Yunjie TongWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States.
Purdue University West Lafayette · USHarvard University · USUniversity Hospital of Zurich · CH

Funding

Image based modeling of biomechanical factors for risk assessment of developing periventricular white matter hyperintensitiesR21AG068962 · NIA · PURDUE UNIVERSITY · PI TONG, YUNJIE · 2021 to 2021
$423k
Probing cerebral hemodynamics in Alzheimer's Disease using novel retrospective delay analysisR21AG070383 · NIA · MCLEAN HOSPITAL · PI HOCKE, LIA MARIA · 2020 to 2020
$410k
A New Multimodal Perfusion Imaging Method Using Concurrent NIRS and fMRIR21DA032746 · NIDA · MCLEAN HOSPITAL · PI FREDERICK, BLAISE DEBONNEVAL · 2012 to 2013
$398k
NIA NIH HHS R21 AG068962NIA NIH HHS R21 AG070383NIDA NIH HHS R21 DA032746
6 · The paper itself

Abstract

Blood arrival time and blood transit time are useful metrics in characterizing hemodynamic behaviors in the brain. Functional magnetic resonance imaging in combination with a hypercapnic challenge has been proposed as a non-invasive imaging tool to determine blood arrival time and replace dynamic susceptibility contrast (DSC) magnetic resonance imaging, a current gold-standard imaging tool with the downsides of invasiveness and limited repeatability. Using a hypercapnic challenge, blood arrival times can be computed by cross-correlating the administered CO

Indexed as

carpet plotcerebral transit timedynamic susceptibility contrast imaginghypercapnia fMRIstructural similarity index

Identifiers

PMID36875021
PMCPMC9975721
OpenAlexW4320917707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.