Evidence map›Paper›PMID 36874938›Full record

ArticleRSC advances2023

Copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides using ethyl bromodifluoroacetate as the bifunctional reagent.

Changdong Shao, Tianyi Xu, Chen Chen, Qionglin Yang, Chao Tang, Ping Chen, Mingzhu Lu, Zhengsong Hu, Huayou Hu, Tingting Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Changdong ShaoJiangsu Provincial Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University Huai'an 223300 Jiangsu China shaochangdong@hytc.edu.cn.ORCID https://orcid.org/0000-0002-8691-5177
Tianyi XuJiangsu Provincial Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University Huai'an 223300 Jiangsu China shaochangdong@hytc.edu.cn.
Chen ChenJiangsu Provincial Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University Huai'an 223300 Jiangsu China shaochangdong@hytc.edu.cn.
Qionglin YangJiangsu Provincial Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University Huai'an 223300 Jiangsu China shaochangdong@hytc.edu.cn.
Chao TangJiangsu Provincial Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University Huai'an 223300 Jiangsu China shaochangdong@hytc.edu.cn.ORCID https://orcid.org/0000-0002-7559-7126
Ping ChenJiangsu Provincial Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University Huai'an 223300 Jiangsu China shaochangdong@hytc.edu.cn.ORCID https://orcid.org/0000-0002-0216-475X
Mingzhu LuJiangsu Provincial Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University Huai'an 223300 Jiangsu China shaochangdong@hytc.edu.cn.ORCID https://orcid.org/0000-0002-6333-0803
Zhengsong HuJiangsu Provincial Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University Huai'an 223300 Jiangsu China shaochangdong@hytc.edu.cn.
Huayou HuJiangsu Provincial Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University Huai'an 223300 Jiangsu China shaochangdong@hytc.edu.cn.ORCID https://orcid.org/0000-0003-4795-0866
Tingting ZhangJiangsu Provincial Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University Huai'an 223300 Jiangsu China shaochangdong@hytc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A simple and effective method for the copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides with ethyl bromodifluoroacetate as the bifunctional reagent was developed. The combination of cupric catalyst and alkaline additive results in a C5-bromination reaction, whereas cuprous catalyst combined with silver additive results in the C5-difluoromethylation reaction. This method has a broad substrate scope and allows for easy and convenient access to desired C5-functionalized quinolones with good to excellent yields.

Identifiers

PMID36874938
PMCPMC9977446

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.