Evidence map›Paper›PMID 36874731›Full record

ArticleCureus2023

Biopsy-Proven Melanosis Coli Initially Diagnosed As Candidiasis on Colonoscopy: A Report of Two Cases From North Central Nigeria.

Kevin N Ezike, Ijeoma A Okwudire-Ejeh, Iliya K Salu, Chidi V Nnabuchi, Michael E Aghahowa, Frank O Ani, Hope M Isaac

Abstract readCase Reports
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Chronic California herbal tea use causing biopsy-provenSAGE open medical case reports · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kevin N EzikeAnatomic Pathology and Forensic Medicine, Nile University of Nigeria, Abuja, NGA.
Ijeoma A Okwudire-EjehAnatomic Pathology and Forensic Medicine, Asokoro District Hospital, Abuja, NGA.
Iliya K SaluSurgery, Nile University of Nigeria, Abuja, NGA.
Chidi V NnabuchiInternal Medicine, Nile University of Nigeria, Abuja, NGA.
Michael E AghahowaSurgery, Nile University of Nigeria, Abuja, NGA.
Frank O AniObstetrics and Gynaecology, Asokoro District Hospital, Abuja, NGA.
Hope M IsaacSurgery, Trust Charitos Hospital, Abuja, NGA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanosis coli is a benign condition, often identified as an incidental finding during colonoscopy, characterized by brown or black pigmentation of the colonic mucosa due to lipofuscin deposition within the cytoplasm of cells. It has been linked to the excessive use of laxatives, particularly those that are anthraquinone-based but also stimulant laxatives and herbal remedies. White patches on colonoscopy in this condition are an extremely rare finding. We present two cases of 31- and 38-year-old, male Nigerians, with a history of chronic constipation and prolonged stimulant laxative use in whom colonoscopy findings of white patches on the colonic mucosa were confirmed on histology to be melanosis coli. Melanosis coli should be considered in the differential diagnosis of patients with chronic constipation and/or prolonged use of laxatives or herbal remedies who exhibit mucosal changes on colonoscopy even if these changes are not black or brown discolorations.

Indexed as

chronic constipationcolonoscopylaxative usemelanosis coliwhitish patches

Identifiers

PMID36874731
PMCPMC9976949

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.