Evidence map›Paper›PMID 36874601›Full record

ArticleEuropean urology open science2023

Genetic Aspects and Molecular Testing in Prostate Cancer: A Report from a Dutch Multidisciplinary Consensus Meeting.

Niven Mehra, Iris Kloots, Michiel Vlaming, Shafak Aluwini, Els Dewulf, Daniela E Oprea-Lager, Henk van der Poel, Herman Stoevelaar, Derya Yakar, Chris H Bangma and 30 more

Abstract read
In one paragraph

Article in European urology open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Niven MehraDepartment of Medical Oncology, Radboud UMC, Nijmegen, The Netherlands.
Iris KlootsDepartment of Medical Oncology, Radboud UMC, Nijmegen, The Netherlands.
Michiel VlamingDivision Laboratories, Pharmacy and biomedical Genetics, Department of Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands.
Shafak AluwiniDepartment of Radiation Oncology, UMCG, Groningen, The Netherlands.
Els DewulfCentre for Decision Analysis & Support, Ismar Healthcare NV, Lier, Belgium.
Daniela E Oprea-LagerDepartment of Radiology & Nuclear Medicine, Amsterdam University Medical Centers, VU University, Amsterdam, The Netherlands.
Henk van der PoelDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Herman StoevelaarCentre for Decision Analysis & Support, Ismar Healthcare NV, Lier, Belgium.
Derya YakarDepartment of Radiology, UMCG, Groningen, The Netherlands.
Chris H BangmaDepartment of Urology, Erasmus MC, Rotterdam, The Netherlands.
Elise BekersDepartment of Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Roderick van den BerghDepartment of Urology, St. Antonius Ziekenhuis Nieuwegein, The Netherlands.
Andries M BergmanDepartment of Medical Oncology and Oncogenomics, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Franchette van den BerkmortelDepartment of Internal Medicine, Zuyderland MC, Sittard, The Netherlands.
Steve BoudewijnsDepartment of Medical Oncology, Bravis Hospital, Roosendaal, The Netherlands.
Winand N M DinjensDepartment of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Jurgen FüttererDepartment of Medical Imaging, Radboud UMC, Nijmegen, The Netherlands.
Tom van der HulleDepartment of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
Guido JensterDepartment of Urology, Erasmus MC, Rotterdam, The Netherlands.
Leonie I KroezeDepartment of Pathology, Radboud UMC, Nijmegen, The Netherlands.
Michel van KruchtenDepartment of Medical Oncology, University Medical Centre Groningen, Groningen, The Netherlands.
Geert van LeendersDepartment of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Pim J van LeeuwenDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Wendy W J de LengDepartment of Pathology, UMC Utrecht, Utrecht, The Netherlands.
R Jeroen A van MoorselaarDepartment of Urology, Amsterdam University Medical Centers, VU University, Amsterdam, The Netherlands.
Walter NoordzijDepartment of Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands.
Rogier A OldenburgDepartment of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.
Inge M van OortDepartment of Urology, Radboud UMC, Nijmegen, The Netherlands.
Irma OvingDepartment of Internal Medicine, Ziekenhuis Groep Twente, Almelo, The Netherlands.
Jack A SchalkenDepartment of Urology, Radboud UMC, Nijmegen, The Netherlands.
Ivo G SchootsDepartment of Radiology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Ed SchuuringDepartment of Pathology, University Medical Center Groningen, Groningen, The Netherlands.
Robert J SmeenkDepartment of Radiation Oncology, Radboud UMC, Nijmegen, The Netherlands.
Ben G L VannesteDepartment of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht UMC, Maastricht, The Netherlands.
Erik VegtDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
André N VisDepartment of Urology, Amsterdam University Medical Centers, VU University, Amsterdam, The Netherlands.
Kim de VriesDepartment of Radiation Oncology, Erasmus MC, Rotterdam, The Netherlands.
Peter-Paul M WillemseDepartment of Urology, Cancer Center, UMC Utrecht, Utrecht, The Netherlands.
Maurits WondergemDepartment of Nuclear Medicine, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Margreet AusemsDivision Laboratories, Pharmacy and biomedical Genetics, Department of Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Germline and tumour genetic testing in prostate cancer (PCa) is becoming more broadly accepted, but testing indications and clinical consequences for carriers in each disease stage are not yet well defined. Objective: To determine the consensus of a Dutch multidisciplinary expert panel on the indication and application of germline and tumour genetic testing in PCa. Design setting and participants: The panel consisted of 39 specialists involved in PCa management. We used a modified Delphi method consisting of two voting rounds and a virtual consensus meeting. Outcome measurements and statistical analysis: Consensus was reached if ≥75% of the panellists chose the same option. Appropriateness was assessed by the RAND/UCLA appropriateness method. Results and limitations: Of the multiple-choice questions, 44% reached consensus. For men without PCa having a relevant family history (familial PCa/ Conclusions: The outcomes of this Dutch consensus meeting may provide further guidance on genetic counselling and molecular testing related to PCa. Patient summary: A group of Dutch specialists discussed the use of germline and tumour genetic testing in prostate cancer (PCa) patients, indication of these tests (which patients and when), and impact of these tests on the management and treatment of PCa.

Indexed as

BRCA1/2Castration-resistant prostate cancerDNA damage repairGenetic counsellingGermline genetic testingMismatch repairProstate cancerTumour genetic testing

Identifiers

PMID36874601
PMCPMC9975012

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.