Evidence map›Paper›PMID 36874496›Full record

ArticleBiomedical optics express2023

Confocal reflectance microscopy for mapping collagen fiber organization in the vitreous gel of the eye.

Eileen S Hwang, Denise J Morgan, Jieliyue Sun, M Elizabeth Hartnett, Kimani C Toussaint, Brittany Coats

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Toward Bioactive Hydrogels: A Tunable Approach via Nucleic Acid-Collagen Complexation.Regenerative engineering and translational medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Eileen S HwangDepartment of Ophthalmology and Visual Sciences, University of Utah, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA.ORCID https://orcid.org/0000-0003-0161-6977
Denise J MorganDepartment of Ophthalmology and Visual Sciences, University of Utah, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA.
Jieliyue SunPROBE lab, School of Engineering, Brown University, Providence, RI 02912, USA.
M Elizabeth HartnettDepartment of Ophthalmology and Visual Sciences, University of Utah, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA.
Kimani C ToussaintPROBE lab, School of Engineering, Brown University, Providence, RI 02912, USA.ORCID https://orcid.org/0000-0002-6701-4541
Brittany CoatsDepartment of Mechanical Engineering, University of Utah, 1495 E 100 S, Salt Lake City, UT 84112, USA.
University of Utah · USJohn Brown University · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jun Yang · 2005 to 2026
$14.6M
Cellular, molecular and physical mechanisms of vitreous structural heterogeneity underlying posterior vitreous detachmentK08EY034549 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Eileen S Hwang · 2023 to 2026
$761k
NCATS NIH HHS UL1 TR002538NEI NIH HHS K08 EY034549NEI NIH HHS P30 EY014800
6 · The paper itself

Abstract

Vitreous collagen structure plays an important role in ocular mechanics. However, capturing this structure with existing vitreous imaging methods is hindered by the loss of sample position and orientation, low resolution, or a small field of view. The objective of this study was to evaluate confocal reflectance microscopy as a solution to these limitations. Intrinsic reflectance avoids staining, and optical sectioning eliminates the requirement for thin sectioning, minimizing processing for optimal preservation of the natural structure. We developed a sample preparation and imaging strategy using

Identifiers

PMID36874496
PMCPMC9979684
OpenAlexW4317895800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.