Evidence map›Paper›PMID 36874382›Full record

Trial reportInternational journal of clinical practice2023

Protective Effects of Dexmedetomidine Infusion on Genotoxic Potential of Isoflurane in Patients Undergoing Emergency Surgery.

Sadaf Aroosa, Adeel Sattar, Aqeel Javeed, Muhammad Usman, Mian Abdul Hafeez, Mehmood Ahmad

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sadaf AroosaDepartment of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Adeel SattarDepartment of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.ORCID https://orcid.org/0000-0003-1124-4046
Aqeel JaveedDepartment of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Muhammad UsmanInstitute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Mian Abdul HafeezDepartment of Parasitology, Faculty of Veterinary Science, University of Veterinary and Animal Sciences, Lahore, Pakistan.ORCID https://orcid.org/0000-0002-3036-7693
Mehmood AhmadDepartment of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
University of Veterinary and Animal Sciences · PKRiphah International University · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Isoflurane (ISO) has been extensively uses in general anesthesia and reported to cause deoxyribonucleic acid (DNA) damage in prolonged surgical procedures. Dexmedetomidine (DEX) is an adrenergic agonist and having antioxidant activity that may reduce the genotoxic potential (DNA damage) and oxidative stress induced by ISO in patients undergoing major neurosurgical procedures. Conclusion: Increased level of antioxidants and decreased value of MDA and genetic damage index were seen in group B (

Indexed as

DexmedetomidineIsofluraneAnesthesia, GeneralAntioxidantsDNA DamageHumansAntioxidantsDexmedetomidineIsoflurane

Identifiers

PMID36874382
PMCPMC9977554
OpenAlexW4321490367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.