Evidence map›Paper›PMID 36874269›Full record

ArticleRheumatology advances in practice2023

Vitamin D status in ANCA-associated vasculitis.

Irena Doubelt, David Cuthbertson, Simon Carette, Nader A Khalidi, Curry L Koening, Carol Langford, Carol A McAlear, Larry W Moreland, Paul Monach, Philip Seo and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Rheumatology advances in practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00315380 (Longitudinal Protocol for Eosinophilic Granulomatosis With Polyangiitis), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00315380 recruitingnot on this map

Longitudinal Protocol for Eosinophilic Granulomatosis With Polyangiitis

TypeobservationalSponsorUniversity of PennsylvaniaRan2006 to 2028Enrolled700ConditionsEosinophilic Granulomatosis With Polyangiitis, Churg-Strauss Syndrome
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Susac syndrome - different treatment approaches for one disease (analysis of case series).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 2 countries.

Irena DoubeltVasculitis Clinic, Mount Sinai Hospital, Department of Rheumatology, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-9629-8053
David CuthbertsonHealth Informatics Institute, University of South Florida, Tampa, FL, USA.
Simon CaretteVasculitis Clinic, Mount Sinai Hospital, Department of Rheumatology, University of Toronto, Toronto, ON, Canada.
Nader A KhalidiDivision of Rheumatology, McMaster University and St. Joseph's Healthcare, Hamilton, ON, Canada.
Curry L KoeningDivision of Rheumatology, University of Utah Hospital, Salt Lake City, UT, USA.
Carol LangfordDivision of Rheumatology, Cleveland Clinic, Cleveland, OH, USA.
Carol A McAlearDivision of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Larry W MorelandDivision of Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA.
Paul MonachDivision of Rheumatology, VA Boston Healthcare System, Boston, MA, USA.
Philip SeoDivision of Rheumatology, Johns Hopkins University, Baltimore, MD, USA.
Ulrich SpecksDivision of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Kenneth J WarringtonDivision of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.ORCID https://orcid.org/0000-0001-7708-2487
Peter A MerkelDivision of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Christian PagnouxVasculitis Clinic, Mount Sinai Hospital, Department of Rheumatology, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-6287-9549
Mount Sinai Hospital · CAUniversity of Pennsylvania · USCleveland Clinic · USJohns Hopkins University · USMayo Clinic · USMayo Clinic in Arizona · USSt. Joseph’s Healthcare Hamilton · CAUniversity of Pittsburgh · USUniversity of South Florida · USUniversity of Utah Hospital · USVA Boston Healthcare System · US

Funding

VCRC-VF FellowshipU54AR057319 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MERKEL, PETER A · 2009 to 2020
$12.5M
NIAMS NIH HHS U54 AR057319
6 · The paper itself

Abstract

Objective: Vitamin D might participate in the pathogenesis of several immune-mediated diseases, but few related data are available for ANCA-associated vasculitis (AAV). In this study, we analysed the association between vitamin D status and disease in patients with AAV. Methods: Serum levels of 25(OH)D Results: Seventy of 125 patients (56%) were female, with a mean age of 51.5 (16) years at diagnosis; 84 (67%) were ANCA positive. Mean 25(OH)D was 37.6 (16) ng/ml, with vitamin D deficiency in 13 (10.4%) and insufficiency in 26 (20.8%). In univariate analysis, lower vitamin D status was associated with male sex ( Conclusion: Most patients with AAV have sufficient 25(OH)D levels, although those with lower vitamin D status were more likely to be male and to have active disease. Whether optimization of vitamin D status alters disease manifestations or activity in AAV remains to be determined. Trial Registration: Vasculitis Clinical Research Consortium (VCRC) Longitudinal Study (LS), NCT00315380, https://clinicaltrials.gov/ct2/show/NCT00315380.

Indexed as

ANCA-associated vasculitiscohort studyeosinophilic granulomatosis with polyangiitisgranulomatosis with polyangiitismicroscopic polyangiitisvitamin D

Identifiers

PMID36874269
PMCPMC9977244
OpenAlexW4319919563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.