ArticleNeurophotonics2023
Open-source statistical and data processing tools for wide-field optical imaging data in mice.
Article in Neurophotonics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Excitatory and inhibitory networks diverge following early blindness.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- The protocol for mesoscopic wide-field optical imaging in mice: from zero to hero.Biology methods & protocols · 2026Review
- Mapping functional connectivity in the pigeon brain with wide-field optical imaging.Neurophotonics · 2026Article
- Psychedelic 5-HTNature neuroscience · 2025Article
- Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans.Nature communications · 2025Article
- PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors.Nature neuroscience · 2025Article
- Bridging the gap: umIT makes complex imaging data accessible to scientists of all backgrounds.Neurophotonics · 2025Article
- Zika virus encephalitis causes transient reduction of functional cortical connectivity.Neurophotonics · 2025Article
- Wide-field imaging in behaving mice as a tool to study cognitive function.Neurophotonics · 2024Review
- The Effects of Acute Stress on Evoked-cortical Connectivity through Wide-field Optical Mapping of Neural and Hemodynamic Signals.Experimental neurobiology · 2024Article
- Visual Deprivation during Mouse Critical Period Reorganizes Network-Level Functional Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Spatial nonstationarity of image noise in widefield optical imaging and its effects on cluster-based inference for resting-state functional connectivity.Journal of neuroscience methods · 2024Article
- Mecp2 deletion results in profound alterations of developmental and adult functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Transient disruption of functional connectivity and depression of neural fluctuations in a mouse model of acute septic encephalopathy.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Controlling the familywise error rate in widefield optical neuroimaging of functional connectivity in mice.Neurophotonics · 2023Article
- Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type.NeuroImage · 2022Article
- Statistical approaches to temporal and spatial autocorrelation in resting-state functional connectivity in mice measured with optical intrinsic signal imaging.Neurophotonics · 2022Article
- SIRT1 mediates hypoxic postconditioning- and resveratrol-induced protection against functional connectivity deficits after subarachnoid hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Functional Connectivity of the Developing Mouse Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Significance: Wide-field optical imaging (WOI) can produce concurrent hemodynamic and cell-specific calcium recordings across the entire cerebral cortex in animal models. There have been multiple studies using WOI to image mouse models with various environmental or genetic manipulations to understand various diseases. Despite the utility of pursuing mouse WOI alongside human functional magnetic resonance imaging (fMRI), and the multitude of analysis toolboxes in the fMRI literature, there is not an available open-source, user-friendly data processing and statistical analysis toolbox for WOI data. Aim: To assemble a MATLAB toolbox for processing WOI data, as described and adapted to combine techniques from multiple WOI groups and fMRI. Approach: We outline our MATLAB toolbox on GitHub with multiple data analysis packages and translate a commonly used statistical approach from the fMRI literature to the WOI data. To illustrate the utility of our MATLAB toolbox, we demonstrate the ability of the processing and analysis framework to detect a well-established deficit in a mouse model of stroke and plot activation areas during an electrical paw stimulus experiment. Results: Our processing toolbox and statistical methods isolate a somatosensory-based deficit 3 days following photothrombotic stroke and cleanly localize sensory stimulus activations. Conclusions: The toolbox presented here details an open-source, user-friendly compilation of WOI processing tools with statistical methods to apply to any biological question investigated with WOI techniques.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.