Evidence map›Paper›PMID 36874207›Full record

ArticleAPL photonics2020

Reconstruction of angle-resolved backscattering through a multimode fiber for cell nuclei and particle size determination.

Haoran Zhang, Zachary A Steelman, Silvia Ceballos, Kengyeh K Chu, Adam Wax

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL photonics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haoran ZhangDepartment of Biomedical Engineering, Duke University, Durham, NC, 227708, USA.
Zachary A SteelmanDepartment of Biomedical Engineering, Duke University, Durham, NC, 227708, USA.
Silvia CeballosDepartment of Biomedical Engineering, Duke University, Durham, NC, 227708, USA.
Kengyeh K ChuDepartment of Biomedical Engineering, Duke University, Durham, NC, 227708, USA.
Adam WaxDepartment of Biomedical Engineering, Duke University, Durham, NC, 227708, USA.

Funding

Advanced a/LCI systems for improved clinical utilityR01CA210544 · NCI · DUKE UNIVERSITY · PI SHAHEEN, NICHOLAS J, WAX, ADAM · 2017 to 2021
$2.7M
NCI NIH HHS R01 CA210544
6 · The paper itself

Abstract

We demonstrate reconstruction of angle-resolved optical backscattering after transmission through a multimode fiber. Angle-resolved backscattering is an important tool for particle sizing, and has been developed as a diagnostic modality for detecting epithelial precancer. In this work, we fully characterized the transfer function of a multimode fiber using a plane-wave illumination basis across two dimensions. Once characterized, angle-resolved scattering information which has been scrambled by multimodal propagation can be easily and accurately reconstructed. Our technique was validated using a Mie theory-based inverse light scattering analysis (ILSA) algorithm on polystyrene microsphere phantoms of known sizes. To demonstrate the clinical potential of this approach, nuclear morphology was determined from the reconstructed angular backscattering from MCF-10A human mammary epithelial cell samples and validated against quantitative image analysis (QIA) of fluorescence microscopy images.

Identifiers

PMID36874207
PMCPMC9980710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.