ArticleJournal of Indian Society of Periodontology
Protein and mRNA expression of interleukin-33 in periodontally diseased and healthy individuals and impact of nonsurgical periodontal therapy in salivary IL-33 levels.
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- Expression of IL-33 in subjects with periodontitis: a systematic review and meta-analysis.European journal of medical research · 2024Pooled it
- Oral and Gingival Crevicular Fluid Biomarkers for Jawbone Turnover Diseases: A Scoping Review.Diagnostics (Basel, Switzerland) · 2024Article
- Evaluation of Serum Interleukin-33 Level in Iraqi Patients with and without Periodontal Disease.Clinical, cosmetic and investigational dentistry · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Interleukin (IL)-33 is a member of IL-1 beta family of cytokines having a pivotal role in bone destruction. However, its role in periodontal disease is not clearly established. The objective of the present study was to evaluate salivary and gingival IL-33 expression in periodontally healthy and diseased individuals. The change in salivary IL-33 after nonsurgical therapy was also analyzed. Materials and Methods: Salivary IL-33 concentration was estimated using enzyme-linked immunosorbent assay in periodontally healthy and diseased individuals (30 in each group). Re-evaluation was done in periodontitis patients after 6 weeks of nonsurgical therapy. Further, the messenger ribonucleic acid expression of IL-33 in healthy and diseased gingival tissues was also examined using reverse transcriptase-polymerase chain reaction and correlated with IL-1 beta messenger ribonucleic acid. Results: Salivary IL-33 concentration in periodontitis patients was 1.65 fold higher than healthy controls ( Conclusion: The study reconfirms the role of IL-33 in periodontal disease, proposed a threshold value of differentiating healthy and periodontitis patients, and suggests IL-33 as a potential diagnostic biomarker for periodontal disease and to evaluate the response to periodontal therapy.
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