Evidence map›Paper›PMID 36873853›Full record

ArticleChemical science2023

Selective chemical reagents to investigate the role of caspase 6 in apoptosis in acute leukemia T cells.

Katarzyna M Groborz, Małgorzata Kalinka, Justyna Grzymska, Sonia Kołt, Scott J Snipas, Marcin Poręba

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. PANoptosis: a new insight for oral diseases.Molecular biology reports · 2024
    Review
  3. Exploring caspase functions in mouse models.Apoptosis : an international journal on programmed cell death · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Katarzyna M GroborzDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology Wyb. Wyspiańskiego 27 50-370 Wroclaw Poland groborzk@gene.com marcin.poreba@pwr.edu.pl.
Małgorzata KalinkaDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology Wyb. Wyspiańskiego 27 50-370 Wroclaw Poland groborzk@gene.com marcin.poreba@pwr.edu.pl.
Justyna GrzymskaDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology Wyb. Wyspiańskiego 27 50-370 Wroclaw Poland groborzk@gene.com marcin.poreba@pwr.edu.pl.
Sonia KołtDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology Wyb. Wyspiańskiego 27 50-370 Wroclaw Poland groborzk@gene.com marcin.poreba@pwr.edu.pl.
Scott J SnipasNCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute 10901 North Torrey Pines Road La Jolla CA 92037 USA.
Marcin PorębaDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology Wyb. Wyspiańskiego 27 50-370 Wroclaw Poland groborzk@gene.com marcin.poreba@pwr.edu.pl.ORCID https://orcid.org/0000-0002-0214-6252
Wrocław University of Science and Technology · PLSanford Burnham Prebys Medical Discovery Institute · US

Funding

Survival Mechanisms for Apoptotic CaspaseR01GM099040 · NIGMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SALVESEN, GUY S. · 2012 to 2020
$3.8M
NIGMS NIH HHS R01 GM099040
6 · The paper itself

Abstract

Activated effector caspases 3, 6 and 7 are responsible for cleaving a number of target substrates, leading to the ultimate destruction of cells

Identifiers

PMID36873853
PMCPMC9977399
OpenAlexW4313528137

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.