ArticleHeliyon2023
Chlorogenic acid rich in coffee pulp extract suppresses inflammatory status by inhibiting the p38, MAPK, and NF-κB pathways.
Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- From Conventional Methods to Innovation: Caffeine and Chlorogenic Acid Extraction and Quantification in the Rise of Smart and Green Techniques-A Systematic Review.Molecules (Basel, Switzerland) · 2026Pooled it
- Potential lipid-lowering effects ofFrontiers in nutrition · 2026Trial
- Therapeutic Efficacy of Carvacrol-Loaded Mesoporous Silicate Nanoparticles Against Cryptosporidiosis.Pharmaceutics · 2026Article
- Chlorogenic acid attenuates LPS-induced hepatic oxidative stress in broilers by regulating cyclooxygenase-2 expression.Poultry science · 2026Article
- Dietary Chlorogenic Acid Attenuates Liver Injury, Lipid Metabolic Disturbance, and Inflammatory Responses in Broilers Under High Stocking Density.Animals : an open access journal from MDPI · 2026Article
- Extracts of Baccharis conferta Kunth Reduce Carrageenan-Induced Paw Edema in Mice and Inhibit NF-κB in LPS-Stimulated RAW-Blue Macrophages.Chemistry & biodiversity · 2026Article
- Chlorogenic Acid Ameliorates CVB3-Induced Viral Myocarditis by Suppressing Viral Replication and ZBP1-Mediated PANoptosis.Microorganisms · 2026Article
- Chlorogenic acid mitigates calcium oxalate monohydrate crystal-induced epithelial-to-mesenchymal transition in renal epithelial cells via suppression of HSP60 expression and p38 signaling.Cellular & molecular biology letters · 2026Article
- Coffea arabica pulp aqueous extract exhibits the anti-colitogenic effect in mice: preventive efficacy and possible mechanisms of action.Biological research · 2026Article
- Vascular endothelial growth factor (VEGF)-related blood flow regulation and anti-inflammation in the protection of Danzhu Fuyuan Granules against cognitive impairment.Metabolic brain disease · 2026Article
- A novel collagen hydrogel loaded with primary brown sugar for accelerating burn wound healing by a synergistic mechanism.Regenerative biomaterials · 2026Article
- DietaryAnimals : an open access journal from MDPI · 2025Article
- The Effect of Caffeine on Wnt/β-Catenine and P38 Mitogen-Activated Protein Kinases (MAPK) Signal Pathways and Some Biochemical Parameters on Cafeteria Diet in Rats.Food science & nutrition · 2025Article
- Chlorogenic acid protects against cisplatin-induced testicular damage: a biochemical and histological study.Arhiv za higijenu rada i toksikologiju · 2025Article
- Phenolic Acids from Fruit By-Products as Therapeutic Agents for Metabolic Syndrome: A Review.International journal of molecular sciences · 2025Review
- Coffee as a Source of Antioxidants and an Elixir of Youth.Antioxidants (Basel, Switzerland) · 2025Review
- The Antimicrobial Effects of Coffee and By-Products and Their Potential Applications in Healthcare and Agricultural Sectors: A State-of-Art Review.Microorganisms · 2025Review
- Phytochemical-richFrontiers in nutrition · 2025Article
- Transforming coffee from an empirical beverage to a targeted nutritional intervention: health effects of coffee's core functional components on chronic diseases.Frontiers in nutrition · 2025Review
- Coffee: Fuel for Your Day or Foe for Your Arteries.Antioxidants (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coffee pulp (CP) is a coffee byproduct that contains various active ingredients, namely, chlorogenic acid (CGA) and caffeine. These active compounds show several benefits, including antihyperlipidemia, antioxidants, and anti-inflammation. However, the anti-inflammatory properties of Coffea pulp extract (CPE) are unknown. This work determined the impact of CPE on lipopolysaccharide (LPS)-activated murine macrophage cells and the molecular mechanism behind this action. RAW 264.7 cells were exposed to varying doses of CPE with or without LPS. Inflammatory markers and their mechanism were studied. CPE therapy has been shown to suppress the synthesis of inflammatory cytokines and mediators, namely, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), IL-1β, cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and nitric oxide (NO), as well as prostaglandin E2 (PGE
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.