Evidence map›Paper›PMID 36873489›Full record

ArticleHeliyon2023

Central venous access devices implantation in children with severe hemophilia a: data from the children comprehensive care center of China.

Qian Xu, Chunli Wang, Wei Cheng, Yingzi Zhen, Yaguang Ding, Guoqing Liu, Wanru Yao, Zhenping Chen, Zhiqiang Li, Runhui Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Qian XuDepartment II of Hematology Center, Haemophilia Comprehensive Care Center, Beijing Children's Hospital, Capital Medical University; National Center for Children's Health, Beijing 100045, China.
Chunli WangNursing Department, Beijing Children's Hospital, Capital Medical University; National Center for Children's Health, Beijing 100045, China.
Wei ChengDepartment of Cardiovascular Surgery II, Beijing Children's Hospital, Capital Medical University; National Center for Children's Health, Beijing 100045, China.
Yingzi ZhenNursing Department, Beijing Children's Hospital, Capital Medical University; National Center for Children's Health, Beijing 100045, China.
Yaguang DingNursing Department, Beijing Children's Hospital, Capital Medical University; National Center for Children's Health, Beijing 100045, China.
Guoqing LiuDepartment II of Hematology Center, Haemophilia Comprehensive Care Center, Beijing Children's Hospital, Capital Medical University; National Center for Children's Health, Beijing 100045, China.
Wanru YaoDepartment II of Hematology Center, Haemophilia Comprehensive Care Center, Beijing Children's Hospital, Capital Medical University; National Center for Children's Health, Beijing 100045, China.
Zhenping ChenDepartment II of Hematology Center, Haemophilia Comprehensive Care Center, Beijing Children's Hospital, Capital Medical University; National Center for Children's Health, Beijing 100045, China.
Zhiqiang LiDepartment of Cardiovascular Surgery II, Beijing Children's Hospital, Capital Medical University; National Center for Children's Health, Beijing 100045, China.
Runhui WuDepartment II of Hematology Center, Haemophilia Comprehensive Care Center, Beijing Children's Hospital, Capital Medical University; National Center for Children's Health, Beijing 100045, China.
Beijing Children’s Hospital · CNNational Center for Women and Children’s Health, China CDC · CNCapital Medical University · CNChengdu Women's and Children's Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To report the perioperative management experience of central venous access devices (CVAD) in Chinese children with severe hemophilia A (SHA) in China. Methods: This retrospective study included SHA children who underwent Port-A-Cath or peripherally inserted central catheter (PICC) implantation between 2020/01 and 2021/07. Collected data included baseline characteristics, factor replacement regimen and CVAD-related complications. Results: Nine patients had nine ports placed, and eight patients underwent 10 PICCs placement. Patients without or with low-titer inhibitor (<5 BU) received a port. The median preoperative and postoperative plasma-derived factor VIII (pd-FVIII) doses were 53.0 (44.4-61.1) and 315.9 (88.2-577.8) IU/kg. The median port duration was 189 (15-512) days, with infection incidence of 0.06 per 1000 CVAD days. Patients with high-titer inhibitors (>10 BU) received PICC. The median recombinant factor VIIa (rFVIIa) dose was 87.47 μg/kg before and for 5-7 doses after implantation over 2-3 days. The median PICC duration was 226.5 days, with infection incidence of 0.12 per 1000 catheter-days. Conclusions: CVADs can be safely implanted in China. PICC implantation is a practical and safe option for SHA children with high-titer inhibitors.

Indexed as

ChildrenFactor replacement regimenHemophilia APeripherally inserted central catheterPort-A-CathVascular access devices

Identifiers

PMID36873489
PMCPMC9976301
OpenAlexW4320035133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.