SynthesisFrontiers in cardiovascular medicine2023
A systematic review and meta-analysis of heart rate variability in COPD.
Synthesis in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07591935 (Artificial Intelligence and Mindfulness Meditation), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Artificial Intelligence and Mindfulness Meditation: Innovative Methods to Reduce Stress Amongst Medical School Students
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Burden of chronic obstructive pulmonary disease among Indian adults: systematic review and meta‑analysis.BMC pulmonary medicine · 2026Pooled it
- Effects of acute high-altitude exposure on heart rate variability: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Oxidative Stress and Inflammatory Cytokines as Drivers of Cardiac Remodeling in COPD Patients.Antioxidants (Basel, Switzerland) · 2026Article
- Immediate Effects of Manual Muscle Stretching on Respiratory Capacity, Heart Rate Variability, and Diaphragmatic Function in Patients With COPD.Annals of rehabilitation medicine · 2026Article
- Cardiovascular Risk During the 90-Day Vulnerable Window After COPD Exacerbations: A Narrative Review.Life (Basel, Switzerland) · 2026Review
- Article
- Endoscopic Lung Volume Reduction with Valves Improves Cardiovascular Adaptability and 6-MWT Performance in Severely Limited COPD Patients.International journal of chronic obstructive pulmonary disease · 2026Article
- Association Between Cardiovascular Comorbidities and Clinical Outcomes in Patients Hospitalized for AECOPD.International journal of chronic obstructive pulmonary disease · 2026Article
- The relation between physical activity and cardiac autonomic dysfunction in patients with chronic obstructive pulmonary disease.PloS one · 2026Article
- Two-week heart rate variability measurements and lung health: a cross-sectional analysis in the ARIC study.Respiratory medicine · 2025Article
- Association of daily lung condition in COPD patients with wearable speech and physiological data.Scientific reports · 2025Article
- Heart Rate Variability Applications in Medical Specialties: A Narrative Review.Applied psychophysiology and biofeedback · 2025Review
- Heart Rate Variability (HRV) in Patients with Sleep Apnea and COPD: A Comprehensive Analysis.Journal of clinical medicine · 2025Review
- Reliability of short-term measurement of heart rate variability on rest in individuals with temporomandibular disorder.Scientific reports · 2025Article
- Effects of Missing Data on Heart Rate Variability Measured From A Smartwatch: Exploratory Observational Study.JMIR formative research · 2025Observational
- Heart Rate Variability and Peripheral Oxygen Saturation Levels in Chronic Obstructive Pulmonary Disease.Cureus · 2025Article
- Unraveling the Role of Oxygen Pulse Variability in Endurance Exercise Training in Individuals with COPD: A Novel Approach to Response of Oxygen Pulse and Quality of Life in Pulmonary Rehabilitation.International journal of chronic obstructive pulmonary disease · 2025Article
- Aerobic exercise training for chronic obstructive pulmonary disease: What is the best regimen to increase heart rate variability?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Article
- Heart Rate Recovery After Cardiopulmonary Exercise Test Predicts Acute Exacerbations in Patients with Moderate Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Article
- Assessment of novel cardiovascular biomarkers in chronic obstructive pulmonary disease.BMC pulmonary medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 10 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic obstructive pulmonary disease (COPD) is associated with disruption in autonomic nervous control of the heart rhythm. We present here quantitative evidence of the reduction in HRV measures as well as the challenges to clinical application of HRV in COPD clinics. Method: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we search in June 2022 Medline and Embase databases for studies reporting HRV in COPD patients using relevant medical subject headings (MeSH) terms. The quality of included studies was assessed using the modified version of the Newcastle-Ottawa Scale (NOS). Descriptive data were extracted, while standardized mean difference was computed for changes in HRV due to COPD. Leave-one-out sensitivity test was performed to assess exaggerated effect size and funnel plots to assess publication bias. Results: The databases search yielded 512 studies, of which we included 27 that met the inclusion criteria. The majority of the studies (73%) had a low risk of bias and included a total of 839 COPD patients. Although there were high between-studies heterogeneity, HRV time and frequency domains were significantly reduced in COPD patients compared with controls. Sensitivity test showed no exaggerated effect sizes and the funnel plot showed general low publication bias. Conclusion: COPD is associated with autonomic nervous dysfunction as measured by HRV. Both sympathetic and parasympathetic cardiac modulation were decreased, but there is still a predominance of sympathetic activity. There is high variability in the HRV measurement methodology, which affects clinical applicability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.