Evidence map›Paper›PMID 36873372›Full record

ArticleFrontiers in bioengineering and biotechnology2023

Biomimetic cardiac tissue chip and murine arteriovenous fistula models for recapitulating clinically relevant cardiac remodeling under volume overload conditions.

Tatyana Isayeva Waldrop, Caleb Graham, William Gard, Kevin Ingle, Travis Ptacek, Nguyen Nguyen, Bailey Lose, Palaniappan Sethu, Timmy Lee

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. A Vein Attempt? Experimental Models for Arteriovenous Fistula Research.Cardiovascular engineering and technology · 2026
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tatyana Isayeva WaldropDepartment of Medicine and Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, United States.
Caleb GrahamDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, United States.
William GardDepartment of Medicine and Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, United States.
Kevin IngleDepartment of Medicine and Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, United States.
Travis PtacekCenter for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL, United States.
Nguyen NguyenDepartment of Medicine and Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, United States.
Bailey LoseDepartment of Medicine and Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, United States.
Palaniappan SethuDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, United States.
Timmy LeeDepartment of Medicine and Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · US

Funding

Autophagy and Arteriovenous Fistula MaturationR01HL153244 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEE, TIMMY C, SHIU, YAN-TING E. · 2021 to 2024
$2.2M
Hemodynamic Adaptation and Vascular Remodeling in Fistula DevelopmentR01HL139692 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEE, TIMMY C · 2018 to 2022
$2.1M
Tissue Chip Models for Cardiovascular Development and DiseaseR01HL148462 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SETHU, PALANIAPPAN · 2020 to 2023
$1.7M
Development and Functional Assessment of Cardiovascular Tissue Engineering Therapy (CVTE) T32 Training GrantT32EB023872 · NIBIB · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROGERS, JACK M, ZHANG, JIANYI · 2018 to 2022
$753k
BLRD VA I01 BX003387NHLBI NIH HHS R01 HL139692NHLBI NIH HHS R01 HL148462NHLBI NIH HHS R01 HL153244NIBIB NIH HHS T32 EB023872
6 · The paper itself

Abstract

Cardiovascular events are the primary cause of death among dialysis patients. While arteriovenous fistulas (AVFs) are the access of choice for hemodialysis patients, AVF creation can lead to a volume overload (VO) state in the heart. We developed a three-dimensional (3D) cardiac tissue chip (CTC) with tunable pressure and stretch to model the acute hemodynamic changes associated with AVF creation to complement our murine AVF model of VO. In this study, we aimed to replicate the hemodynamics of murine AVF models

Indexed as

arteriovenous fistulacardiac remodelingend stage renal diseaseheart failuretissue chiptissue engineering

Identifiers

PMID36873372
PMCPMC9978753
OpenAlexW4321087830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.