ArticleFrontiers in psychiatry2023
Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophrenia.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Continuity of Care and Patient Outcomes in Populations With Schizophrenia: A Systematic Review.Psychiatric services (Washington, D.C.) · 2026Pooled it
- "Short" Versus "Long" Duration of Untreated Psychosis in People with First-Episode Psychosis: A Systematic Review and Meta-Analysis of Baseline Status and Follow-Up Outcomes.Schizophrenia bulletin · 2025Pooled it
- A review of functionality assessment scales in schizophrenia.Frontiers in psychiatry · 2025Pooled it
- Impact of Rural Dwelling on Emergency Department Visits for Individuals with Psychotic Disorders in Newfoundland and Labrador, Canada.Schizophrenia bulletin · 2026Article
- Documentation of Psychosis Risk Screening in Same-Day Adolescent Behavioural Health Consultations.Early intervention in psychiatry · 2026Article
- Impact of age of onset on the course of chronic schizophrenia: factors associated with first hospitalization in a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2026Article
- Mind the delay: duration of untreated psychosis is associated with short-term outcomes in first-episode schizophrenia.Frontiers in psychiatry · 2026Article
- Gender-specific symptom outcomes on cariprazine treatment: a 12-month naturalistic longitudinal follow-up study in schizophrenia.Frontiers in psychiatry · 2026Article
- Changes in quality of life among people with psychosis and their caregivers participating in a community-based rehabilitation intervention in Malawi: A mixed-methods analysis.PLOS mental health · 2026Article
- A new two-hit animal model for schizophrenia research: Consequences on social behavior.IBRO neuroscience reports · 2025Article
- Enhancing Coordinated Specialty Care Through Early Detection: Impact of Reduced Duration of Untreated Psychosis.Schizophrenia bulletin · 2025Article
- What is behind the 17-year life expectancy gap between individuals with schizophrenia and the general population?Schizophrenia (Heidelberg, Germany) · 2025Article
- "Young People Come to Youth Workers First": A Mixed Methods Evaluation of the Role of Youth Workers in Youth Psychosis Detection.Early intervention in psychiatry · 2025Article
- Deeper insight into speech characteristics of patients at ultra-high risk using classification and explainability models.Frontiers in psychiatry · 2025Article
- Impact of COVID-19 on emergency department visits for individuals with psychotic disorders in Newfoundland and Labrador, Canada: A longitudinal study.PLOS global public health · 2025Article
- The Impact of Prolonged Duration of Untreated Illness on Clinical Correlates in Chronic Schizophrenia: Exploring the Relationship With Suicide Risk.Psychiatry investigation · 2024Article
- Predicting new onset thought disorder in early adolescence with optimized deep learning implicates environmental-putamen interactions.medRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To explore the relationship between the Duration of Untreated Psychosis (DUP) and long-term clinical outcome, cognitive and social function in patients with chronic schizophrenia (SCZ). Methods: A total of 248 subjects with chronic SCZ were enrolled in this study, including 156 in the short DUP group and 92 in the long DUP group. The Positive and Negative Symptoms Scale (PANSS), the Brief Negative Symptoms Scale (BNSS), the Global Assessment of Functioning (GAF) scale and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were used to assess all of the subjects. Results: The negative symptom scores (the PANSS and BNSS) of subjects with long DUP were significantly higher than that in subjects with short DUP. The scores of visual span and speech function in the short DUP group were significantly higher, indicative of decreasing cognitive function with time. In terms of social function, the short DUP group scored higher, with a statistically significant difference. Meanwhile, we found that the length of DUP was positively correlated with the negative symptom score of the PANSS, negatively correlated with visual span scores, and GAF scores. Conclusion: This study demonstrated that the DUP remained a significant association with negative symptom and cognition in long period of chronic SCZ.
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