Evidence map›Paper›PMID 36873113›Full record

ArticleJournal of medicine and life2023

Autologous hematopoietic bone marrow and concentrated growth factor transplantation combined with core decompression in patients with avascular necrosis of the femoral head.

Nasser Ghaly Yousif, Adnan Essa Kadhum Al Kilabi, Karrar Kareem Hatem, Hamdullah Hadi Al-Albaseesee, Wejdi Abbass Yassin Al-Fatlawy, Majid Alhamadani, Ulrich Aran Nöth, Ahmed Altmimi

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In one paragraph

Article in Journal of medicine and life, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nasser Ghaly YousifDepartment of Medicine, Medical College, Al Muthanna University, Samawah, Iraq.
Adnan Essa Kadhum Al KilabiDepartment of Surgery, Medical College, Kufa University, Kufa, Iraq.
Karrar Kareem HatemDepartment of Surgery, Medical College, Jabir Ibn Hayyan Medical University, Najaf, Iraq.
Hamdullah Hadi Al-AlbaseeseeDepartment of Surgery, Medical College, Kufa University, Kufa, Iraq.
Wejdi Abbass Yassin Al-FatlawyDepartment of Surgery, Medical College, Kufa University, Kufa, Iraq.
Majid AlhamadaniDepartment of Surgery, Ministry of Health, Al Muthanna, Iraq.
Ulrich Aran NöthDepartment of Regenerative Research, College of Medicine, Colorado University, Boulder, Colorado.
Ahmed AltmimiDepartment of Biology, Ministry of Health, Al Muthanna, Iraq.
University of Kufa · IQUniversity of Alkafeel · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aimed to assess the effectiveness of autologous hematopoietic bone marrow and concentrated growth factor (CGF) transplantation and core decompression in patients with avascular necrosis of the femoral head (ANFH). We performed a single-center prospective study on 31 patients with non-traumatic early-stage (stage I to III) ANFH based on the 1994 classification of the Association Research Circulation Osseous (ARCO). The patients were subjected to bone marrow aspiration from the posterior iliac crest, separation, and concentration of growth factors from the bone marrow aspirate, core decompression of the femoral head, and injection of hematopoietic bone marrow and CGFs into the necrotic lesion. Patients were evaluated using the visual analogue scale, the WOMAC questionnaire, and X-ray and MRI examinations of the hip joints before, at 2, 4, and 6 months after the intervention. Patients had a mean age of 33 years (range 20-44 years), 19 (61%) of them being male and 12 (39%) females. The presentation of the disease was bilateral in 21 patients and unilateral in 10 patients. The main cause of ANFH was steroid treatment. The mean VAS and WOMAC scores were 48.37 (SD: 14.67) out of 100, and the mean VAS pain score was 50.83 out of 100 (SD: 20.46), respectively, before transplant. This value significantly improved to 22.31 (SD 12.12) of 100, and the mean VAS pain score was 21.31 of 100 (SD: 20.46) (P=0.04). MRI showed a significant improvement (P=0.012). Our results suggest that autologous hematopoietic bone marrow and CGFs transplantation with core decompression have a beneficial effect in early-stage ANFH.

Indexed as

Femur Head NecrosisHematopoietic Stem Cell TransplantationAdultBone MarrowDecompressionFemaleHumansIntercellular Signaling Peptides and ProteinsMaleProspective StudiesYoung AdultIntercellular Signaling Peptides and ProteinsANFH – avascular necrosis of the femoral headautologous hematopoietic bone marrow transplantationavascular necrosis of the femoral headCGF – concentrated growth factorCI – confidence intervalconcentrated growth factorcore decompressionCT – computed tomographyHIV – human immunodeficiency virusVAS – visual analogue scaleWOMAC – Western Ontario and McMaster Universities Osteoarthritis Index

Identifiers

PMID36873113
PMCPMC9979168
OpenAlexW4323293766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.