Evidence map›Paper›PMID 36873048›Full record

ArticleFrontiers in allergy2023

Chemical modification by peroxynitrite enhances TLR4 activation of the grass pollen allergen Phl p 5.

Kathrin Reinmuth-Selzle, Iris Bellinghausen, Anna Lena Leifke, Anna T Backes, Nadine Bothen, Kira Ziegler, Michael G Weller, Joachim Saloga, Detlef Schuppan, Kurt Lucas and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in allergy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Kathrin Reinmuth-SelzleMultiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany.
Iris BellinghausenDepartment of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Anna Lena LeifkeMultiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany.
Anna T BackesMultiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany.
Nadine BothenMultiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany.
Kira ZieglerMultiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany.
Michael G WellerFederal Institute for Materials Research and Testing (BAM), Berlin, Germany.
Joachim SalogaDepartment of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Detlef SchuppanInstitute of Translational Immunology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Kurt LucasMultiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany.
Ulrich PöschlMultiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany.
Janine Fröhlich-NowoiskyMultiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany.
Max Planck Institute for Chemistry · DEJohannes Gutenberg University Mainz · DEFederal Institute For Materials Research and Testing · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chemical modification of aeroallergens by reactive oxygen and nitrogen species (ROS/RNS) may contribute to the growing prevalence of respiratory allergies in industrialized countries. Post-translational modifications can alter the immunological properties of proteins, but the underlying mechanisms and effects are not well understood. In this study, we investigate the Toll-like receptor 4 (TLR4) activation of the major birch and grass pollen allergens Bet v 1 and Phl p 5, and how the physiological oxidant peroxynitrite (ONOO

Indexed as

air pollutionallergyBet v 1dimersnitrationoligomersperoxynitritePhl p 5

Identifiers

PMID36873048
PMCPMC9975604
OpenAlexW4320918910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.