Evidence map›Paper›PMID 36872954›Full record

ArticleJournal of mass spectrometry and advances in the clinical lab2023

Pre-analytical sample handling standardization for reliable measurement of metabolites and lipids in LC-MS-based clinical research.

A Sens, S Rischke, L Hahnefeld, E Dorochow, S M G Schäfer, D Thomas, M Köhm, G Geisslinger, F Behrens, R Gurke

Open access · goldAbstract read
In one paragraph

Article in Journal of mass spectrometry and advances in the clinical lab, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

A SensPharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
S RischkePharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
L HahnefeldPharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
E DorochowPharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
S M G SchäferFraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
D ThomasPharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
M KöhmFraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
G GeisslingerPharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
F BehrensFraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
R GurkePharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Goethe University Frankfurt · DEFraunhofer Institute for Translational Medicine and Pharmacology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emerging disciplines of lipidomics and metabolomics show great potential for the discovery of diagnostic biomarkers, but appropriate pre-analytical sample-handling procedures are critical because several analytes are prone to

Indexed as

1-AG, 1-arachidonoyl glycerol1-LG, 1-linoleoyl glycerol2-AG, 2-arachidonoyl glycerol2-LG, 2- linoleoyl glycerolACN, acetonitrileAEA, arachidonoyl ethanolamideBHT, 2,6-di-tert-butyl-4-methylphenolCAR, carnitineEC, endocannabinoidFC, fold changeFT, freezing temperature/storage in ice waterHETE, hydroxyeicosatetraenoateHRMS, high-resolution mass spectrometryIRB, Institutional Review BoardIS, internal standardK3EDTA plasma samplingK3EDTA, tripotassium ethylenediaminetetraacetic acidLC, liquid chromatographyLEA, linoleoyl ethanolamideLipidomicsLLE, liquid–liquid extractionLLOQ, lowest limit of quantificationLPA, lysophosphatidic acidLPC, lysophosphatidylcholineLPC O, lysophosphatidylcholine-etherLPE, lysophosphatidylethanolamineLPG, lysophosphatidylglycerolLPI, lysophosphatic inositolMeOH, methanolMetabolomicsMS/MS, tandem mass spectrometryMTBE, methyl tertiary-butyl etherOEA, oleoyl ethanolamidePBS, phosphate-buffered salinePC, phohsphatidylcholinePEA, palmitoyl ethanolamidePE, phosphotidylethanolaminePI, phosphatidylinositolPre-analyticsQC, quality controlREC, Research Ethics CommitteeRef, reference sampleRT, room temperatureSampling protocolSEA, stearoyl ethanolamideSPE, solid-phase extractionSTD, calibration standardVEA, vaccenic acid ethanolamidWB, whole blood

Identifiers

PMID36872954
PMCPMC9975683
OpenAlexW4321019953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.