Evidence map›Paper›PMID 36872776›Full record

ArticleJournal of Alzheimer's disease : JAD2023

Population-Based Mini-Mental State Examination Norms in Adults of Mexican Heritage in the Cameron County Hispanic Cohort.

Avram S Bukhbinder, Miriam Hinojosa, Kristofer Harris, Xiaojin Li, Christine M Farrell, Madison Shyer, Nathan Goodwin, Sahar Anjum, Omar Hasan, Susan Cooper and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Avram S BukhbinderDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Miriam HinojosaDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Kristofer HarrisDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Xiaojin LiDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Christine M FarrellDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Madison ShyerDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Nathan GoodwinDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Sahar AnjumDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Omar HasanDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Susan CooperDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Lois ScibaDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Amanda Falk VargasDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
David H HunterDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Guadalupe J OrtizDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Karen ChungDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Licong CuiSchool of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA.
Guo-Qiang ZhangDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Susan P Fisher-HochDepartment of Epidemiology, Human Genetics & Environmental Sciences, UTHealth School of Public Health, Brownsville, TX, USA.
Joseph B McCormickDepartment of Epidemiology, Human Genetics & Environmental Sciences, UTHealth School of Public Health, Brownsville, TX, USA.
Paul E SchulzDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
The University of Texas Health Science Center at Houston · USUniversity of Texas Health Science Center at Dallas · US

Funding

Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
NCATS NIH HHS UL1 TR000371
6 · The paper itself

Abstract

backgroundAccurately identifying cognitive changes in Mexican American (MA) adults using the Mini-Mental State Examination (MMSE) requires knowledge of population-based norms for the MMSE, a scale which has widespread use in research settings.

objectiveTo describe the distribution of MMSE scores in a large cohort of MA adults, assess the impact of MMSE requirements on their clinical trial eligibility, and explore which factors are most strongly associated with their MMSE scores.

methodsVisits between 2004-2021 in the Cameron County Hispanic Cohort were analyzed. Eligible participants were ≥18 years old and of Mexican descent. MMSE distributions before and after stratification by age and years of education (YOE) were assessed, as was the proportion of trial-aged (50-85- year-old) participants with MMSE <24, a minimum MMSE cutoff most frequently used in Alzheimer's disease (AD) clinical trials. As a secondary analysis, random forest models were constructed to estimate the relative association of the MMSE with potentially relevant variables.

resultsThe mean age of the sample set (n = 3,404) was 44.4 (SD, 16.0) years old and 64.5% female. Median MMSE was 28 (IQR, 28-29). The percentage of trial-aged participants (n = 1,267) with MMSE <24 was 18.6% overall and 54.3% among the subset with 0-4 YOE (n = 230). The five variables most associated with the MMSE in the study sample were education, age, exercise, C-reactive protein, and anxiety.

conclusionThe minimum MMSE cutoffs in most phase III prodromal-to-mild AD trials would exclude a significant proportion of trial-aged participants in this MA cohort, including over half of those with 0-4 YOE.

Indexed as

Alzheimer DiseaseMental Status and Dementia TestsMexican AmericansAdultAgedAged, 80 and overEducational StatusFemaleHumansMaleMiddle AgedReference ValuesTexasCameron County Hispanic Cohortclinical trial eligibilityMexican AmericansMini-Mental State Examination

Identifiers

PMID36872776
PMCPMC10200241
OpenAlexW4323040681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.