Evidence map›Paper›PMID 36872608›Full record

ReviewJournal of magnetic resonance imaging : JMRI2023

Updates on LI-RADS Treatment Response Criteria for Hepatocellular Carcinoma: Focusing on MRI.

Richa Patel, Anum Aslam, Neehar D Parikh, Benjamin Mervak, Eman Mubarak, Lily Higgins, Kayli Lala, Jack F Conner, Valerie Khaykin, Mustafa Bashir and 7 more

Open access · greenAbstract readReview
In one paragraph

Review in Journal of magnetic resonance imaging : JMRI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Current State of Evidence for Use of MRI in LI-RADS.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  7. Article
  8. Article
  9. LI-RADS CT/MRI Treatment Response Assessment Update in 2024.Journal of the Korean Society of Radiology · 2025
    Review
  10. Assessment of viable tumours by [European journal of nuclear medicine and molecular imaging · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 1 country.

Richa PatelDepartment of Radiology, Stanford, California, USA.
Anum AslamDepartment of Radiology, University of Michigan Medicine, Ann Arbor, Michigan, USA.
Neehar D ParikhDepartment of Internal Medicine, University of Michigan Medicine, Ann Arbor, Michigan, USA.
Benjamin MervakDepartment of Radiology, University of Michigan Medicine, Ann Arbor, Michigan, USA.
Eman MubarakDepartment of Radiology, University of Michigan Medicine, Ann Arbor, Michigan, USA.
Lily HigginsDepartment of Radiology, University of Michigan Medicine, Ann Arbor, Michigan, USA.
Kayli LalaDepartment of Radiology, University of Michigan Medicine, Ann Arbor, Michigan, USA.
Jack F ConnerDepartment of Radiology, University of Toledo Medical Center, Toledo, Ohio, USA.
Valerie KhaykinDepartment of Radiology and Hepatology, University of Michigan Medicine, Michigan, USA.
Mustafa BashirDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, USA.
Richard Kinh Gian DoDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-6554-0310
Lauren M B BurkeDepartment of Radiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Elainea N SmithDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Charles Y KimDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, USA.
Kimberly L ShampainDepartment of Radiology, University of Michigan Medicine, Ann Arbor, Michigan, USA.
Dawn OwenDepartment of Radiation Oncology, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Mishal Mendiratta-LalaDepartment of Radiology, University of Michigan Medicine, Ann Arbor, Michigan, USA.ORCID 0000-0003-4055-916X
University of Michigan · USDuke Medical Center · USMayo Clinic · USMemorial Sloan Kettering Cancer Center · USStanford Medicine · USUniversity of Alabama at Birmingham · USUniversity of North Carolina at Chapel Hill · USUniversity of Toledo Medical Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

As the incidence of hepatocellular carcinoma (HCC) and subsequent treatments with liver-directed therapies rise, the complexity of assessing lesion response has also increased. The Liver Imaging Reporting and Data Systems (LI-RADS) treatment response algorithm (LI-RADS TRA) was created to standardize the assessment of response after locoregional therapy (LRT) on contrast-enhanced CT or MRI. Originally created based on expert opinion, these guidelines are currently undergoing revision based on emerging evidence. While many studies support the use of LR-TRA for evaluation of HCC response after thermal ablation and intra-arterial embolic therapy, data suggest a need for refinements to improve assessment after radiation therapy. In this manuscript, we review expected MR imaging findings after different forms of LRT, clarify how to apply the current LI-RADS TRA by type of LRT, explore emerging literature on LI-RADS TRA, and highlight future updates to the algorithm. EVIDENCE LEVEL: 3. TECHNICAL EFFICACY: Stage 2.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsContrast MediaData SystemsHumansMagnetic Resonance ImagingRetrospective StudiesSensitivity and SpecificityContrast Mediahepatocellular carcinomaLiver Imaging Data and Reporting System treatment response algorithmlocoregional therapytreatment response assessment

Identifiers

PMID36872608
PMCPMC11078141
OpenAlexW4323293933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.