ArticleSurgery2023
Characteristics and symptomatology of colorectal cancer in the young.
Article in Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Phase angle assessed by bioelectrical impedance analysis in patients with colorectal cancer: a systematic review.Frontiers in oncology · 2026Pooled it
- Clinicopathological characteristics and biomarker alterations in early-onset vs. late-onset colorectal cancer: a systematic review and meta-analysis.International journal of surgery (London, England) · 2026Pooled it
- Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- The Role of Computational Models in the Detection of Colorectal Carcinoma and Precancerous Lesions.International journal of molecular sciences · 2026Review
- Quality of life assessment for colorectal cancer follow-up: A latent profile analysis of EORTC measures.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
- Insights into the Relevance of the Interaction between Colorectal Cancer and Gut Microbiota-Derived Metabolites.Journal of cancer prevention · 2026Review
- Pediatric Colorectal Cancer in Africa: A Multicenter Study on Epidemiology, Management, and Outcomes Between 2000 and 2023.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Polymicrobial retroperitoneal abscess by Salmonella enteritidis and Bacteroides fragilis unmasking cecal cancer.Revista da Sociedade Brasileira de Medicina Tropical · 2026Article
- The Importance of 14-3-3 Proteins in Colorectal Cancer Regulation: Mechanisms of Function and Clinical Opportunities.BioMed research international · 2026Review
- Colorectal cancer in young: a 5-year study from a sub-Saharan African country.BMC gastroenterology · 2025Article
- Risk modeling of delayed postoperative bleeding after endoscopic submucosal dissection for early colorectal cancer and precancerous lesions.World journal of gastrointestinal surgery · 2025Article
- Constipation as an Atypical Presentation of Hyperparathyroidism: A Case Report.The American journal of case reports · 2025Article
- Sex Differences in Colorectal Cancer: Epidemiology, Risk Factors, and Clinical Outcomes.Journal of clinical medicine · 2025Review
- Right-Sided Versus Left-Sided Colon Cancer-A 5-Year Single-Center Observational Study.Cancers · 2025Article
- Regulatory role of PPAR in colorectal cancer.Cell death discovery · 2025Review
- Colonoscopy Uptake in First-Degree Relatives of CRC Patients: Challenges and Intervention Strategies.Patient preference and adherence · 2025Review
- Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy.Biomolecules · 2024Review
- Comprehensive analysis of the prognostic value of pre-treatment nutritional indicators in elderly rectal cancer patients.Scientific reports · 2024Article
- Early Symptom Patterns by Tumor Laterality, Age at Onset, Stage, and Symptom-to-Treatment Initiation in Patients with Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe incidence of colorectal cancer in patients <50 years has rapidly risen recently. Understanding the presenting symptoms may facilitate earlier diagnosis. We aimed to delineate patient characteristics, symptomatology, and tumor characteristics of colorectal cancer in a young population.
methodsA retrospective cohort study was conducted evaluating patients <50 years diagnosed between 2005 and 2019 with primary colorectal cancer at a university teaching hospital. The number and character of colorectal cancer-related symptoms at presentation was the primary outcome measured. Patient and tumor characteristics were also collected.
resultsIncluded were 286 patients with a median age of 44 years, with 56% <45 years. Nearly all patients (95%) were symptomatic at presentation, with 85% having 2 or more symptoms. The most common symptoms were pain (63%), followed by change in stool habits (54%), rectal bleeding (53%), and weight loss (32%). Diarrhea was more common than constipation. More than 50% had symptoms for at least 3 months before diagnosis. The number and duration of symptoms were similar in patients older than 45 compared to those younger. Most cancers were left-sided (77%) and advanced stage at presentation (36% stage III, 39% stage IV).
conclusionIn this cohort of young patients with colorectal cancer, the majority presented with multiple symptoms having a median duration of 3 months. It is essential that providers be mindful of the ever-increasing incidence of colorectal malignancy in young patients, and that those with multiple, durable symptoms should be offered screening for colorectal neoplasms based on symptoms alone.
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