Evidence map›Paper›PMID 36872133›Full record

SynthesisEuropean urology2023

Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry.

Fei Chen, Ravi K Madduri, Alex A Rodriguez, Burcu F Darst, Alisha Chou, Xin Sheng, Anqi Wang, Jiayi Shen, Edward J Saunders, Suhn K Rhie and 108 more

Registry-linked trialOpen access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01221168 (ProGene), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01221168 recruitingnot on this map

ProGene: Etude Genetique et Epidemiologique du Cancer de la Prostate Familial

TypeobservationalSponsorCentre de Recherche sur les Pathologies ProstatiquesRan1996 to 2026Enrolled10,000ConditionsProstate Cancer
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

118 authors at 20 institutions in 9 countries.

Fei ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ravi K MadduriArgonne National Laboratory, Lemont, IL, USA.
Alex A RodriguezArgonne National Laboratory, Lemont, IL, USA.
Burcu F DarstDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Alisha ChouDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Xin ShengDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Anqi WangDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jiayi ShenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Edward J SaundersThe Institute of Cancer Research, London, UK.
Suhn K RhieDepartment of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jeannette T BensenDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sue A InglesDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rick A KittlesDepartment of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Sara S StromDepartment of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Benjamin A RybickiDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Barbara NemesureDepartment of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.
William B IsaacsJames Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD, USA.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Maureen SandersonDepartment of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA.
Esther M JohnDepartment of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Jong Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Jianfeng XuProgram for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.
Ying WangDepartment of Population Science, American Cancer Society, Kennesaw, GA, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Chad D HuffDepartment of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Edward D YeboahUniversity of Ghana Medical School, Accra, Ghana.
Yao TetteyDepartment of Pathology, University of Ghana, Accra, Ghana; Korle Bu Teaching Hospital, Accra, Ghana.
Joseph LachanceSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Wei TangLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Christopher T RentschYale School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven, CT, USA; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Kelly ChoDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; VA Boston Healthcare System, Jamaica Plain, MA, USA.
Benjamin H McmahonTheoretical Biology Division, Los Alamos National Lab, Los Alamos, NM, USA.
Richard B BiritwumKorle Bu Teaching Hospital, Accra, Ghana.
Andrew A AdjeiDepartment of Pathology, University of Ghana Medical School, Accra, Ghana.
Evelyn TayKorle Bu Teaching Hospital, Accra, Ghana.
Ann TrueloveWestat, Rockville, MD, USA.
Shelley NiwaWestat, Rockville, MD, USA.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Kosj YamoahDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA; Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Adam B MurphyDepartment of Urology, Northwestern University, Chicago, IL, USA.
Dana C CrawfordDepartment of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
Alpa V PatelDepartment of Population Science, American Cancer Society, Kennesaw, GA, USA.
William S BushDepartment of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
Melinda C AldrichDivision of Epidemiology, Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Olivier CussenotDepartment of Urology and Predictive Onco-Urology Group, Sorbonne Université, GRC 5 Predictive Onco-Urology, APHP-Sorbonne Université, Paris, France; CeRePP, Tenon Hospital, Paris, France.
Gyorgy PetrovicsDepartment of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Jennifer CullenDepartment of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA; Department of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Christine M Neslund-DudasDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Mariana C SternDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Zsofia Kote-JaraiThe Institute of Cancer Research, London, UK.
Koveela GovindasamiThe Institute of Cancer Research, London, UK.
Michael B CookDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Anand P ChokkalingamSchool of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Ann W HsingDepartment of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Thomas J HoffmannDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Bettina F DrakeDivision of Public Health Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Jennifer J HuThe University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA.
Jacob M KeatonDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Jacklyn N HellwegeDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Nashville, TN, USA.
Peter E ClarkAtrium Health/Levine Cancer Institute, Charlotte, NC, USA.
Mohamed JallohHôpital Général Idrissa Pouye, Dakar, Senegal.
Serigne M GueyeHôpital Général Idrissa Pouye, Dakar, Senegal.
Lamine NiangHôpital Général Idrissa Pouye, Dakar, Senegal.
Olufemi OgunbiyiCollege of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.
Michael O IdowuCollege of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.
Olufemi PopoolaCollege of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.
Akindele O AdebiyiCollege of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.
Oseremen I Aisuodionoe-ShadrachCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria.
Hafees O AjibolaCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria.
Mustapha A JamdaCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria.
Olabode P OluwoleCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria.
Maxwell NwegbuCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria.
Ben Adusei37 Military Hospital, Accra, Ghana.
Sunny Mante37 Military Hospital, Accra, Ghana.
Afua Darkwa-AbrahamsKorle Bu Teaching Hospital, Accra, Ghana.
James E MensahKorle Bu Teaching Hospital, Accra, Ghana.
Halimatou DiopLaboratoires Bacteriologie et Virologie, Hôpital Aristide Le Dantec, Dakar, Senegal.
Stephen K Van Den EedenDivision of Research, Kaiser Permanente, Northern California, Oakland, CA, USA; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
Pascal BlanchetCHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Pointe-à-Pitre, Guadeloupe, France.
Jay H FowkeDepartment of Preventive Medicine, Division of Epidemiology, The University of Tennessee Health Science Center, Memphis, TN, USA.
Graham CaseyDepartment of Public Health Science, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Anselm J HennisDepartment of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.
Alexander LubwamaUro Care, Kampala, Uganda.
Ian M ThompsonCHRISTUS Santa Rosa Medical Center Hospital, San Antonio, TX, USA.
Robin LeachDepartment of Urology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Douglas F EastonDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Michael H PreussThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ruth J LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Susan M GundellDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Peggy WanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
James L MohlerLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Elizabeth T FonthamSchool of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Gary J SmithDepartment of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Jack A TaylorEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Shiv SrivastavaDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Rosaline A EelesThe Institute of Cancer Research, London, UK; Royal Marsden NHS Foundation Trust, London, UK.
John D CarptenDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Adam S KibelDepartment of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Luc MultignerUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Rennes, France.
Marie-Élise ParentEpidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Laval, QC, Canada.
Florence MenegauxCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif Cédex, France; Paris-Sud University, Villejuif Cédex, France.
Geraldine Cancel-TassinDepartment of Urology and Predictive Onco-Urology Group, Sorbonne Université, GRC 5 Predictive Onco-Urology, APHP-Sorbonne Université, Paris, France; CeRePP, Tenon Hospital, Paris, France.
Eric A KleinCleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Caroline AndrewsHarvard TH Chan School of Public Health and Division of Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA; Glickman Urological & Kidney Institute, Cleveland, OH, USA.
Timothy R RebbeckHarvard TH Chan School of Public Health and Division of Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA.
Laurent BrureauCHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Pointe-à-Pitre, Guadeloupe, France.
Stefan AmbsLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Todd L EdwardsDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Stephen WatyaUro Care, Kampala, Uganda.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
John S WitteDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA; Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; International Epidemiology Institute, Rockville, MD, USA.
J Michael GazianoDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA.
Amy C JusticeYale School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven, CT, USA.
David V ContiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Christopher A HaimanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: haiman@usc.edu.
Northwestern University · USUniversity of Southern California · USFred Hutch Cancer Center · USNational Cancer Institute · USHenry Ford Hospital · USHôpital Principal de Dakar · SNKorle Bu Teaching Hospital · GHMoffitt Cancer Center · USUniversity of Abuja Teaching Hospital · NGUniversity of Ghana · GHUniversity of Ibadan · NGVanderbilt University Medical Center · USWestat (United States) · USArgonne National Laboratory · USLos Alamos National Laboratory · USStony Brook University · US37 Military Hospital · GHAmerican Cancer Society · USAssistance Publique – Hôpitaux de Paris · FRCase Western Reserve University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI William JAMES GAUDERMAN, KIMBERLY D SIEGMUND · 2016 to 2026
$25.5M
Research on Prostate Cancer in Men of African Ancestry: Defining the Roles of Genetics, Immunity and Stress (RESPOND)U19CA214253 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAIMAN, CHRISTOPHER ALAN · 2018 to 2023
$16.8M
Maryland Prostate Cancer Case-Control StudyZIABC010499 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI AMBS, STEFAN · 2009 to 2025
$11.4M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
The Molecular Profile of Prostate Tumors in African-American MenZIABC010624 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI AMBS, STEFAN · 2009 to 2025
$8.0M
PCPT and SELECT Cohorts: Core Infrastructure Support for Cancer ResearchU01CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2019 to 2023
$5.4M
Leveraging Prospective Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk ScoresU01CA261339 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fei Chen, David V Conti · 2021 to 2026
$5.2M
Multiethnic GWAS and TWAS to Inform Risk Prediction for Prostate CancerU01CA257328 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CONTI, DAVID V, HAIMAN, CHRISTOPHER ALAN · 2021 to 2025
$3.1M
Multidisciplinary Training in Ethnic Diversity and Cancer DisparitiesT32CA229110 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2019 to 2023
$2.1M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P01 CA196569NCI NIH HHS T32 CA229110NCI NIH HHS U01 CA182883NCI NIH HHS U01 CA257328NCI NIH HHS U01 CA261339NCI NIH HHS U19 CA148537NCI NIH HHS U19 CA214253NCI NIH HHS UG1 CA189974NIAMS NIH HHS K12 AR084232NICHD NIH HHS K12 HD043483
6 · The paper itself

Abstract

backgroundGenetic factors play an important role in prostate cancer (PCa) susceptibility.

objectiveTo discover common genetic variants contributing to the risk of PCa in men of African ancestry. DESIGN, SETTING, AND

participantsWe conducted a meta-analysis of ten genome-wide association studies consisting of 19378 cases and 61620 controls of African ancestry. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Common genotyped and imputed variants were tested for their association with PCa risk. Novel susceptibility loci were identified and incorporated into a multiancestry polygenic risk score (PRS). The PRS was evaluated for associations with PCa risk and disease aggressiveness. RESULTS AND LIMITATIONS: Nine novel susceptibility loci for PCa were identified, of which seven were only found or substantially more common in men of African ancestry, including an African-specific stop-gain variant in the prostate-specific gene anoctamin 7 (ANO7). A multiancestry PRS of 278 risk variants conferred strong associations with PCa risk in African ancestry studies (odds ratios [ORs] >3 and >5 for men in the top PRS decile and percentile, respectively). More importantly, compared with men in the 40-60% PRS category, men in the top PRS decile had a significantly higher risk of aggressive PCa (OR = 1.23, 95% confidence interval = 1.10-1.38, p = 4.4 × 10

conclusionsThis study demonstrates the importance of large-scale genetic studies in men of African ancestry for a better understanding of PCa susceptibility in this high-risk population and suggests a potential clinical utility of PRS in differentiating between the risks of developing aggressive and nonaggressive disease in men of African ancestry. PATIENT SUMMARY: In this large genetic study in men of African ancestry, we discovered nine novel prostate cancer (PCa) risk variants. We also showed that a multiancestry polygenic risk score was effective in stratifying PCa risk, and was able to differentiate risk of aggressive and nonaggressive disease.

Indexed as

Genetic Predisposition to DiseaseProstatic NeoplasmsBlack PeopleGenome-Wide Association StudyHumansMaleRisk FactorsAfrican ancestryAggressive prostate cancerPolygenic risk scoreProstate cancerSusceptibility loci

Identifiers

PMID36872133
PMCPMC10424812
OpenAlexW4323043273

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.