Evidence map›Paper›PMID 36871613›Full record

Observational studyJournal of cardiac failure2023

Exertional Cardiac and Pulmonary Vascular Hemodynamics in Patients With Heart Failure With Reduced Ejection Fraction.

Justin A Edward, Hugh Parker, Eric J Stöhr, Barry J McDonnell, Katie O'Gean, Margaret Schulte, Justin S Lawley, William K Cornwell

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cardiac failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03078972 (Effective Mechanical Circulatory Support on Exercise Capacity in Heart Failure), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03078972 unknown statusnot on this map

Effective Mechanical Circulatory Support on Exercise Capacity in Heart Failure

TypeobservationalSponsorUniversity of Colorado, DenverRan2017 to 2023Enrolled60ConditionsHeart Failure，Congestive
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Justin A EdwardDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO.
Hugh ParkerDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO.
Eric J StöhrLeibniz University Hannover, COR-HELIX (Cardiovascular Regulation and Human Exercise Laboratory-Integration and Xploration), Hannover, Germany; Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York NY, USA.
Barry J McDonnellCardiovascular Physiology Research Group, Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom.
Katie O'GeanClinical Translational Research Center, University of Colorado Anschutz Medical Campus, Aurora, CO.
Margaret SchulteClinical Translational Research Center, University of Colorado Anschutz Medical Campus, Aurora, CO.
Justin S LawleyUniversity of Innsbruck, Department of Sport Science, Innsbruck, Austria.
William K CornwellDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO; Clinical Translational Research Center, University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address: william.cornwell@cuanschutz.edu.

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Effect of Mechanical Circulatory Support on Exercise Capacity in Heart FailureK23HL132048 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI CORNWELL, WILLIAM · 2016 to 2020
$819k
NCATS NIH HHS UL1 TR002535NHLBI NIH HHS K23 HL132048
6 · The paper itself

Abstract

backgroundExertional dyspnea is a cardinal manifestation of heart failure with reduced ejection fraction (HFrEF), but quantitative data regarding exertional hemodynamics are lacking.

objectivesWe sought to characterize exertional cardiopulmonary hemodynamics in patients with HFrEF.

methodsWe studied 35 patients with HFrEF (59 ± 12 years old, 30 males) who completed invasive cardiopulmonary exercise testing. Data were collected at rest, at submaximal exercise and at peak effort on upright cycle ergometry. Cardiovascular and pulmonary vascular hemodynamics were recorded. Fick cardiac output (Qc) was determined. Hemodynamic predictors of peak oxygen uptake (VO

resultsLeft ventricular ejection fraction and cardiac index were 23% ± 8% and 2.9 ± 1.1 L/min/m

conclusionsPatients with HFrEF suffer from marked increases in filling pressures during exercise. These findings provide new insight into cardiopulmonary abnormalities contributing to impairments in exercise capacity in this population. CLINICAL

trial registrationclinicaltrials.gov identifier: NCT03078972.

Indexed as

Heart FailureVentricular Dysfunction, LeftAgedCardiac OutputExercise TestExercise ToleranceFemaleHemodynamicsHumansMaleMiddle AgedOxygen ConsumptionStroke VolumeVentricular Function, LeftExerciseHeart failure with reduced ejection fractionHemodynamicsPulmonary vascular disease

Identifiers

PMID36871613
PMCPMC10477310

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.