ArticleNeurobiology of aging2023
Sleep quality and sleep duration predict brain microstructure among community-dwelling older adults.
Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Associations among sleep quality, cognitive decline, and Alzheimer's disease pathology in older adults: A longitudinal study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- CRP Is a Key Indicator of Rheumatoid Arthritis-Associated Vascular Injury and Neurodegeneration.International journal of molecular sciences · 2026Review
- Polygenic Index for Sleep Duration and Brain Changes over Time.Medical sciences (Basel, Switzerland) · 2026Article
- Sleep duration, depressive symptoms, and postoperative delirium: a mediation analysis.Frontiers in psychiatry · 2026Article
- Can we predict sleep health based on brain features? A large-scale machine learning study using the UK Biobank.Brain communications · 2026Article
- Brain Age Acceleration on MRI Due to Poor Sleep: Associations, Mechanisms, and Clinical Implications.Brain sciences · 2025Review
- Brain Microstructural Alteration and Its Implications for Postoperative Delirium in Elderly Surgical Patients: A Narrative Review.Brain and behavior · 2025Review
- The association between poor sleep health and Alzheimer's disease structural neuroimaging biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Modifiable Risk Factors for Cognitive Decline in Community-Dwelling Older Adults Differ by Sex and APOE4.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Long sleep duration, cognitive performance, and the moderating role of depression: A cross-sectional analysis in the Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sleep disorders and the association with frailty among community-dwelling older adults in Northwest China: a cross-sectional study.BMJ open · 2025Article
- Cardiorespiratory Fitness and Sleep, but not Physical Activity, are Associated with Functional Connectivity in Older Adults.Sports medicine - open · 2024Article
- Poor sleep and decreased cortical thickness in veterans with mild traumatic brain injury and post-traumatic stress disorder.Military Medical Research · 2024Article
- Knowledge atlas of white matter microstructure: a bibliometric analysis.Quantitative imaging in medicine and surgery · 2024Article
- Association of Sleep Duration and Change Over Time With Imaging Biomarkers of Cerebrovascular, Amyloid, Tau, and Neurodegenerative Pathology.Neurology · 2024Article
- Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders.Frontiers in psychiatry · 2024Article
- Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Gender-and age-specific associations of sleep duration and quality with cognitive impairment in community-dwelling older adults in Anhui Province, China.Frontiers in public health · 2023Article
- The link between sleep duration and stroke risk.Brain circulationArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Although poor sleep quality and extreme sleep durations have been associated with brain atrophy and dementia, it is unclear whether sleep disturbances contribute to neural injury in the absence of neurodegeneration and cognitive impairment. In 146 dementia-free older adults of the Rancho Bernardo Study of Healthy Aging (76.7 ± 7.8 years at MRI), we examined associations of restriction spectrum imaging metrics of brain microstructure with self-reported sleep quality 6.3 ± 0.7 years prior, and with sleep duration reported 25, 15 and 9 years prior. Worse sleep quality predicted lower white matter restricted isotropic diffusion and neurite density and higher amygdala free water, with stronger associations between poor sleep quality and abnormal microstructure for men. Among women only, short or long sleep duration 25 and 15 years before MRI predicted lower white matter restricted isotropic diffusion and increased free water. Associations persisted after accounting for associated health and lifestyle factors. Sleep patterns were not related to brain volume or cortical thickness. Optimizing sleep behaviors throughout the life-course may help to preserve healthy brain aging.
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