ArticleCirculation. Heart failure2023
Exposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock.
Article in Circulation. Heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The effects of mechanical ventilation during v-a ecmo support: a systematic review.Critical care (London, England) · 2026Pooled it
- Severe hyperoxia during VA-ECMO promotes oxidative stress and multi-organ injury in an experimental rat model of septic cardiomyopathy.Journal of translational medicine · 2026Article
- How to optimize brain perfusion and prevent cerebral complications during extracorporeal life support.Intensive care medicine · 2026Review
- Acid-Base Status During Venoarterial Extracorporeal Membrane Oxygenator Support in Patients With Cardiogenic Shock.Journal of the American Heart Association · 2026Article
- Impact of early hyperoxia on outcomes during neonatal and pediatric veno-arterial extracorporeal life support★.The journal of extra-corporeal technology · 2026Article
- Death by Neurologic Criteria in Neonates Undergoing Extracorporeal Membrane Oxygenation: Extracorporeal Life Support Organization Registry Study, 2010-2023.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026Article
- Optimal ECLS Support in Mixed Cardiogenic and Septic Shock: An ELSO Registry Analysis.JACC. Advances · 2025Article
- Normoxemic Extracorporeal Membrane Oxygenation Reduces Infarct Size and Preserves Mitochondrial Integrity in Preclinical Models of Acute Myocardial Infarction.Journal of cardiovascular translational research · 2025Article
- A simple VA-ECMO bundle in adult patients with cardiogenic shock: an analysis of ELSO registry.EClinicalMedicine · 2025Article
- Partial arterial carbon dioxide and oxygen pressure in patients with cardiogenic shock.Internal and emergency medicine · 2025Article
- Correspondence by Augustin et al. regarding the article "Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation".Intensive care medicine · 2025Article
- Pulse Pressure and Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation: An Extracorporeal Life Support Organization Registry Analysis.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2025Article
- Hyperoxia as a driver of gut dysbiosis.Frontiers in microbiology · 2025Review
- Personalized oxygen targets are needed for extracorporeal membrane oxygenation.Intensive care medicine · 2024Article
- Novel Role for Cardiolipin as a Target of Therapy to Mitigate Myocardial Injury Caused by Venoarterial Extracorporeal Membrane Oxygenation.Circulation · 2024Article
- Oxygenation management during veno-arterial ECMO support for cardiogenic shock: a multicentric retrospective cohort study.Annals of intensive care · 2024Article
- Impact of hyperoxia on the gut during critical illnesses.Critical care (London, England) · 2024Review
- Timing of Initiation of Extracorporeal Membrane Oxygenation Support and Outcomes Among Patients With Cardiogenic Shock.Journal of the American Heart Association · 2024Article
- Article
- Response by Jentzer et al to Letters Regarding Article, "Exposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock".Circulation. Heart failure · 2023Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundExposure to hyperoxia, a high arterial partial pressure of oxygen (PaO2), may be associated with worse outcomes in patients receiving extracorporeal membrane oxygenator (ECMO) support. We examined hyperoxia in the Extracorporeal Life Support Organization Registry among patients receiving venoarterial ECMO for cardiogenic shock.
methodsWe included Extracorporeal Life Support Organization Registry patients from 2010 to 2020 who received venoarterial ECMO for cardiogenic shock, excluding extracorporeal CPR. Patients were grouped based on PaO2 after 24 hours of ECMO: normoxia (PaO2 60-150 mmHg), mild hyperoxia (PaO2 151-300 mmHg), and severe hyperoxia (PaO2 >300 mmHg). In-hospital mortality was evaluated using multivariable logistic regression.
resultsAmong 9959 patients, 3005 (30.2%) patients had mild hyperoxia and 1972 (19.8%) had severe hyperoxia. In-hospital mortality increased across groups: normoxia, 47.8%; mild hyperoxia, 55.6% (adjusted odds ratio, 1.37 [95% CI, 1.23-1.53];
conclusionsExposure to hyperoxia during venoarterial ECMO support for cardiogenic shock is strongly associated with increased in-hospital mortality, independent from hemodynamic and ventilatory status. Until clinical trial data are available, we suggest targeting a normal PaO2 and avoiding hyperoxia in CS patients receiving venoarterial ECMO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.